PDF(Pubmed)
Abstract：
UNASSIGNED: Malignant hyperthermia (MH) is a potentially life-threatening pharmacogenetic syndrome triggered by volatile anaesthetics, succinylcholine, and stress such as vigorous exercise.
UNASSIGNED: The authors describe a case of an 8-year-old male who presented with classical symptoms of MH after induction of general anaesthesia and symptomatic treatment was done successfully due to the unavailability of Dantrolene.
UNASSIGNED: Definitive diagnosis of MH can be done based on a contracture test in fresh muscle biopsy in the presence of halothane and caffeine. In the absence of muscle biopsy and genetic testing, diagnosis for MH can be done based on MH scoring.
UNASSIGNED: Anesthesiologists should be made aware that proper symptomatic management can also save the life of a patient. Also, strong advocacy should be done to ensure the availability of Dantrolene and further strengthen lab facilities to confirm diagnosis to facilitate diagnosis and management in the future.
UNASSIGNED: The authors describe a case of an 8-year-old male who presented with classical symptoms of MH after induction of general anaesthesia and symptomatic treatment was done successfully due to the unavailability of Dantrolene.
UNASSIGNED: Definitive diagnosis of MH can be done based on a contracture test in fresh muscle biopsy in the presence of halothane and caffeine. In the absence of muscle biopsy and genetic testing, diagnosis for MH can be done based on MH scoring.
UNASSIGNED: Anesthesiologists should be made aware that proper symptomatic management can also save the life of a patient. Also, strong advocacy should be done to ensure the availability of Dantrolene and further strengthen lab facilities to confirm diagnosis to facilitate diagnosis and management in the future.
摘要：
■恶性高热（MH）是由挥发性麻醉剂引发的潜在危及生命的药物遗传综合征，琥珀酰胆碱，以及剧烈运动等压力。
■作者描述了一例8岁男性，他在全身麻醉诱导后出现MH的典型症状，对症治疗由于丹曲林不可用而成功完成。
■MH的明确诊断可以基于在氟烷和咖啡因存在下的新鲜肌肉活检中的挛缩测试来进行。在没有肌肉活检和基因检测的情况下，MH的诊断可以根据MH评分进行。
■麻醉医师应该意识到，适当的对症管理也可以挽救患者的生命。此外，应大力倡导确保Danthroene的可用性，并进一步加强实验室设施以确认诊断，以促进将来的诊断和管理。
■作者描述了一例8岁男性，他在全身麻醉诱导后出现MH的典型症状，对症治疗由于丹曲林不可用而成功完成。
■MH的明确诊断可以基于在氟烷和咖啡因存在下的新鲜肌肉活检中的挛缩测试来进行。在没有肌肉活检和基因检测的情况下，MH的诊断可以根据MH评分进行。
■麻醉医师应该意识到，适当的对症管理也可以挽救患者的生命。此外，应大力倡导确保Danthroene的可用性，并进一步加强实验室设施以确认诊断，以促进将来的诊断和管理。
