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Abstract：
UNASSIGNED: Stem cell transplantation is a clinical approach used to treat certain types of cancers, such as hematologic malignancies. Graft-versus-host disease (GVHD) occurs in 30-70% of cases and often diminishes the quality of life of transplant patients. This study aimed to determine the prevalence of vaginal complications of GVHD following hematopoietic stem cell transplantation.
UNASSIGNED: This study employed an analytical cross-sectional design. All patients referred to Shariati Hospital in Tehran between 2019 and 2020 who underwent hematopoietic stem cell transplantation were considered for inclusion in this study if they met the inclusion criteria. Inclusion criteria encompassed nonnot sexually active women aged 18-70 who received stem cell transplantation more than 100 days prior. Exclusion criteria comprised patients who experienced GVHD during the first 100 days posttransplantation. Additionally, individuals over 75 and patients with metastatic cancer were excluded.
UNASSIGNED: A total of 55 patients were recruited, with ages averaging 40±9.9 years for recipients and 38.5±12.8 years for donors. Notably, 63.3 and 58.2% of patients exhibited oral and ocular symptoms, respectively. Regarding genital involvement, 49.1% experienced vaginal symptoms, while 25.5% had vulvar involvement. Among the 27 patients with vaginal involvement, two (7.4%) were categorized as mild, 17 (63%) as moderate, and eight (29.6%) as severe. Univariate analysis identified reduced vaginal discharge [odds ratio (OR=6.56)], vaginal tightness (OR=6.23), pelvic pain (OR=5.50), and vaginal involvement (OR=3.81) as significant predictors of other organ symptoms. Moreover, vaginal involvement (OR=3.68) emerged as the sole significant predictor of the cooccurrence of oral, ocular, and other organ symptoms. In the multivariate analysis, reduced vaginal discharge (OR=8.24) and vaginal tightness (OR=3.92) significantly predicted other organ symptoms (P=0.009).
UNASSIGNED: Reduced vaginal discharge and vaginal tightness remained significant predictors of other organ symptoms.
UNASSIGNED: This study employed an analytical cross-sectional design. All patients referred to Shariati Hospital in Tehran between 2019 and 2020 who underwent hematopoietic stem cell transplantation were considered for inclusion in this study if they met the inclusion criteria. Inclusion criteria encompassed nonnot sexually active women aged 18-70 who received stem cell transplantation more than 100 days prior. Exclusion criteria comprised patients who experienced GVHD during the first 100 days posttransplantation. Additionally, individuals over 75 and patients with metastatic cancer were excluded.
UNASSIGNED: A total of 55 patients were recruited, with ages averaging 40±9.9 years for recipients and 38.5±12.8 years for donors. Notably, 63.3 and 58.2% of patients exhibited oral and ocular symptoms, respectively. Regarding genital involvement, 49.1% experienced vaginal symptoms, while 25.5% had vulvar involvement. Among the 27 patients with vaginal involvement, two (7.4%) were categorized as mild, 17 (63%) as moderate, and eight (29.6%) as severe. Univariate analysis identified reduced vaginal discharge [odds ratio (OR=6.56)], vaginal tightness (OR=6.23), pelvic pain (OR=5.50), and vaginal involvement (OR=3.81) as significant predictors of other organ symptoms. Moreover, vaginal involvement (OR=3.68) emerged as the sole significant predictor of the cooccurrence of oral, ocular, and other organ symptoms. In the multivariate analysis, reduced vaginal discharge (OR=8.24) and vaginal tightness (OR=3.92) significantly predicted other organ symptoms (P=0.009).
UNASSIGNED: Reduced vaginal discharge and vaginal tightness remained significant predictors of other organ symptoms.
摘要：
■干细胞移植是一种用于治疗某些类型癌症的临床方法，如血液系统恶性肿瘤。移植物抗宿主病（GVHD）发生在30-70％的病例中，通常会降低移植患者的生活质量。本研究旨在确定造血干细胞移植后GVHD阴道并发症的发生率。
■这项研究采用了分析横截面设计。2019年至2020年期间转诊到德黑兰Shariati医院接受造血干细胞移植的所有患者，如果符合纳入标准，则考虑纳入本研究。纳入标准包括18-70岁的非性活跃女性，她们在100天前接受干细胞移植。排除标准包括在移植后的前100天期间经历GVHD的患者。此外,超过75岁的个体和转移性癌症患者被排除在外.
■共招募了55名患者，接受者的平均年龄为40±9.9岁，捐赠者的平均年龄为38.5±12.8岁。值得注意的是,63.3和58.2％的患者出现口腔和眼部症状，分别。关于生殖器受累，49.1%出现阴道症状，而25.5%有外阴受累。在27例阴道受累患者中，两个（7.4%）被归类为轻度，17（63%）为中等，严重的有8人(29.6%)。单变量分析确定阴道分泌物减少[比值比（OR=6.56）]，阴道紧绷度（OR=6.23），盆腔疼痛（OR=5.50），和阴道受累（OR=3.81）是其他器官症状的重要预测因子。此外，阴道受累（OR=3.68）是口腔同时发生的唯一重要预测因素，眼,和其他器官症状。在多变量分析中，阴道分泌物减少(OR=8.24)和阴道紧绷(OR=3.92)可显著预测其他器官症状(P=0.009)。
阴道分泌物减少和阴道紧绷仍然是其他器官症状的重要预测因素。
■这项研究采用了分析横截面设计。2019年至2020年期间转诊到德黑兰Shariati医院接受造血干细胞移植的所有患者，如果符合纳入标准，则考虑纳入本研究。纳入标准包括18-70岁的非性活跃女性，她们在100天前接受干细胞移植。排除标准包括在移植后的前100天期间经历GVHD的患者。此外,超过75岁的个体和转移性癌症患者被排除在外.
■共招募了55名患者，接受者的平均年龄为40±9.9岁，捐赠者的平均年龄为38.5±12.8岁。值得注意的是,63.3和58.2％的患者出现口腔和眼部症状，分别。关于生殖器受累，49.1%出现阴道症状，而25.5%有外阴受累。在27例阴道受累患者中，两个（7.4%）被归类为轻度，17（63%）为中等，严重的有8人(29.6%)。单变量分析确定阴道分泌物减少[比值比（OR=6.56）]，阴道紧绷度（OR=6.23），盆腔疼痛（OR=5.50），和阴道受累（OR=3.81）是其他器官症状的重要预测因子。此外，阴道受累（OR=3.68）是口腔同时发生的唯一重要预测因素，眼,和其他器官症状。在多变量分析中，阴道分泌物减少(OR=8.24)和阴道紧绷(OR=3.92)可显著预测其他器官症状(P=0.009)。
阴道分泌物减少和阴道紧绷仍然是其他器官症状的重要预测因素。
