PDF(Pubmed)
Abstract：
UNASSIGNED: Multiple sclerosis (MS) is a chronic inflammatory condition that impacts the central nervous system. It is distinguished by processes like demyelination, gliosis, neuro-axonal harm, and inflammation. The prevailing theory suggests that MS originates from an immune response directed against the body\'s own antigens within the central nervous system.
UNASSIGNED: The main aim of this research paper \"Neuroinflammation-on-a-Chip\" for studying multiple sclerosis is to enhance our comprehension of MS development, demonstrate the application of cutting-edge technology, and potentially provide valuable insights for therapeutic approaches.
UNASSIGNED: The available literature for this Narrative Review was searched on various bibliographic databases, PubMed, NCBI, and many other medical references using an individually verified, prespecified approach. Studies regarding the significance of MS and its neuroinflammatory pathogenesis in addition to the development and optimization of neuroinflammatory-on-a-chip and the advancement in innovations in this field have been reviewed in this research for a better understanding of \"Neuroinflammation-on-a-chip for multiple sclerosis\". The level of evidence of the included studies was considered as per the Centre for Evidence-Based Medicine recommendations.
UNASSIGNED: Several studies have indicated that the brain-chip model closely mimics cortical brain tissue compared to commonly used conventional cell culture methods like the Transwell culture system. Additionally, these studies have clearly demonstrated that further research using brain chips has the potential to enhance our understanding of the molecular mechanisms and roles of blood-brain barrier (BBB) transporters in both normal and disease conditions.
UNASSIGNED: Understanding neuroinflammation processes remains essential to establish new MS treatments approaches. The utilization of brain chips promises to advance our understanding of the molecular processes involving BBB transporters, both in normal and diseased states. Further research needs to be addressed in order to enhance the performance and understanding of neuroinflammation on a chip, hence aiming to provide more effective treatments for all CNS diseases.
UNASSIGNED: The main aim of this research paper \"Neuroinflammation-on-a-Chip\" for studying multiple sclerosis is to enhance our comprehension of MS development, demonstrate the application of cutting-edge technology, and potentially provide valuable insights for therapeutic approaches.
UNASSIGNED: The available literature for this Narrative Review was searched on various bibliographic databases, PubMed, NCBI, and many other medical references using an individually verified, prespecified approach. Studies regarding the significance of MS and its neuroinflammatory pathogenesis in addition to the development and optimization of neuroinflammatory-on-a-chip and the advancement in innovations in this field have been reviewed in this research for a better understanding of \"Neuroinflammation-on-a-chip for multiple sclerosis\". The level of evidence of the included studies was considered as per the Centre for Evidence-Based Medicine recommendations.
UNASSIGNED: Several studies have indicated that the brain-chip model closely mimics cortical brain tissue compared to commonly used conventional cell culture methods like the Transwell culture system. Additionally, these studies have clearly demonstrated that further research using brain chips has the potential to enhance our understanding of the molecular mechanisms and roles of blood-brain barrier (BBB) transporters in both normal and disease conditions.
UNASSIGNED: Understanding neuroinflammation processes remains essential to establish new MS treatments approaches. The utilization of brain chips promises to advance our understanding of the molecular processes involving BBB transporters, both in normal and diseased states. Further research needs to be addressed in order to enhance the performance and understanding of neuroinflammation on a chip, hence aiming to provide more effective treatments for all CNS diseases.
摘要：
■多发性硬化症（MS）是一种影响中枢神经系统的慢性炎症。它的特点是脱髓鞘，胶质增生,神经轴突损伤,和炎症。流行的理论表明，MS起源于针对中枢神经系统内人体自身抗原的免疫反应。
■这篇研究论文“芯片上的神经炎症”研究多发性硬化症的主要目的是增强我们对MS发展的理解，展示尖端技术的应用，并可能为治疗方法提供有价值的见解。
■在各种书目数据库中搜索了本叙事评论的可用文献，PubMed,NCBI,和许多其他医疗参考使用单独验证，预先规定的方法。除了芯片上神经炎症的开发和优化以及该领域的创新进展外，有关MS及其神经炎症发病机制的重要性的研究已经在这项研究中进行了综述，以更好地理解“神经炎症-多发性硬化症的芯片”。根据循证医学中心的建议，考虑了纳入研究的证据水平。
■一些研究表明，与通常使用的常规细胞培养方法（如Transwell培养系统）相比，脑芯片模型紧密模仿皮质脑组织。此外,这些研究清楚地表明,使用脑芯片的进一步研究有可能增强我们对血脑屏障(BBB)转运蛋白在正常和疾病状态下的分子机制和作用的理解.
■了解神经炎症过程对于建立新的MS治疗方法仍然至关重要。脑芯片的利用有望提高我们对涉及BBB转运蛋白的分子过程的理解，在正常和患病状态。需要进一步的研究，以提高芯片上神经炎症的性能和理解，因此旨在为所有CNS疾病提供更有效的治疗。
■这篇研究论文“芯片上的神经炎症”研究多发性硬化症的主要目的是增强我们对MS发展的理解，展示尖端技术的应用，并可能为治疗方法提供有价值的见解。
■在各种书目数据库中搜索了本叙事评论的可用文献，PubMed,NCBI,和许多其他医疗参考使用单独验证，预先规定的方法。除了芯片上神经炎症的开发和优化以及该领域的创新进展外，有关MS及其神经炎症发病机制的重要性的研究已经在这项研究中进行了综述，以更好地理解“神经炎症-多发性硬化症的芯片”。根据循证医学中心的建议，考虑了纳入研究的证据水平。
■一些研究表明，与通常使用的常规细胞培养方法（如Transwell培养系统）相比，脑芯片模型紧密模仿皮质脑组织。此外,这些研究清楚地表明,使用脑芯片的进一步研究有可能增强我们对血脑屏障(BBB)转运蛋白在正常和疾病状态下的分子机制和作用的理解.
■了解神经炎症过程对于建立新的MS治疗方法仍然至关重要。脑芯片的利用有望提高我们对涉及BBB转运蛋白的分子过程的理解，在正常和患病状态。需要进一步的研究，以提高芯片上神经炎症的性能和理解，因此旨在为所有CNS疾病提供更有效的治疗。
