PDF(Pubmed)
Abstract：
UNASSIGNED: Syncope is a serious consequence in patients with hypertrophic obstructive cardiomyopathy (HOCM). Percutaneous endocardial septal radiofrequency ablation (PESA) has emerged as a promising intervention to alleviate symptoms and enhance the quality of life for HOCM patients. However, little is known about the effects of PESA on syncope in HOCM. The authors aimed to study the effects of PESA on syncope in patients with HOCM.
UNASSIGNED: Nineteen patients with HOCM and syncope were enrolled. The left ventricular outflow tract gradient (LVOTG) of the patients was more than 50 mmHg despite medication. The participants underwent PESA under the guidance of intracardiac echocardiography (ICE) combined with a three-dimensional electrophysiological mapping system. The patients were followed for 3 (3-5.5) months.
UNASSIGNED: The mean age of the patients was 54.8±13.7 years. Out of the 19 participants, 7 (37%) were females. During the follow-up, the syncope was completely alleviated in 14 patients (73.7%) or the syncope episodes were reduced greater than or equal to 80% in 16 patients (84.2%). The mean NYHA functional class significantly improved from 2.2±0.7 at baseline to 1.7±0.6 during follow-up (P=0.002). The LVOTG and septal thickness showed a decreasing trend from baseline to follow-up (LVOTG: P=0.083, septal thickness: P=0.086).
UNASSIGNED: The authors\' investigation provides evidence supporting the effectiveness of PESA in reducing syncope episodes in patients with HOCM.
UNASSIGNED: Nineteen patients with HOCM and syncope were enrolled. The left ventricular outflow tract gradient (LVOTG) of the patients was more than 50 mmHg despite medication. The participants underwent PESA under the guidance of intracardiac echocardiography (ICE) combined with a three-dimensional electrophysiological mapping system. The patients were followed for 3 (3-5.5) months.
UNASSIGNED: The mean age of the patients was 54.8±13.7 years. Out of the 19 participants, 7 (37%) were females. During the follow-up, the syncope was completely alleviated in 14 patients (73.7%) or the syncope episodes were reduced greater than or equal to 80% in 16 patients (84.2%). The mean NYHA functional class significantly improved from 2.2±0.7 at baseline to 1.7±0.6 during follow-up (P=0.002). The LVOTG and septal thickness showed a decreasing trend from baseline to follow-up (LVOTG: P=0.083, septal thickness: P=0.086).
UNASSIGNED: The authors\' investigation provides evidence supporting the effectiveness of PESA in reducing syncope episodes in patients with HOCM.
摘要：
■晕厥是肥厚型梗阻性心肌病（HOCM）患者的严重后果。经皮心内膜间隔射频消融（PESA）已成为一种有希望的干预措施，可缓解HOCM患者的症状并提高生活质量。然而,关于PESA对HOCM晕厥的影响知之甚少。作者旨在研究PESA对HOCM患者晕厥的影响。
■纳入19例HOCM和晕厥患者。尽管药物治疗，患者的左心室流出道梯度（LVOTG）仍超过50mmHg。参与者在心内超声心动图（ICE）结合三维电生理标测系统的指导下接受了PESA。随访3(3-5.5)个月。
■患者的平均年龄为54.8±13.7岁。在19名参与者中，7（37%）为女性。在后续行动中,14例患者(73.7%)晕厥完全缓解,16例患者(84.2%)晕厥发作减少大于或等于80%.平均NYHA功能等级从基线时的2.2±0.7显著改善至随访期间的1.7±0.6(P=0.002)。从基线到随访，LVOTG和间隔厚度均呈下降趋势（LVOTG：P=0.083，间隔厚度：P=0.086）。
作者的调查提供了证据支持PESA在减少HOCM患者晕厥发作方面的有效性。
■纳入19例HOCM和晕厥患者。尽管药物治疗，患者的左心室流出道梯度（LVOTG）仍超过50mmHg。参与者在心内超声心动图（ICE）结合三维电生理标测系统的指导下接受了PESA。随访3(3-5.5)个月。
■患者的平均年龄为54.8±13.7岁。在19名参与者中，7（37%）为女性。在后续行动中,14例患者(73.7%)晕厥完全缓解,16例患者(84.2%)晕厥发作减少大于或等于80%.平均NYHA功能等级从基线时的2.2±0.7显著改善至随访期间的1.7±0.6(P=0.002)。从基线到随访，LVOTG和间隔厚度均呈下降趋势（LVOTG：P=0.083，间隔厚度：P=0.086）。
作者的调查提供了证据支持PESA在减少HOCM患者晕厥发作方面的有效性。
