PDF(Pubmed)
Abstract：
Carbamazepine, a commonly prescribed antiepileptic drug, is known to induce hiccups in a subset of epileptic patients. Although relatively uncommon, can have significant clinical implications. This comprehensive review delves into the clinical and electroencephalographic correlates of carbamazepine-associated hiccups, aiming to enhance understanding and management of this neurological side effect. The authors\' review synthesizes qualitative epidemiological data, revealing that carbamazepine-induced hiccups occur in a subset of patients receiving the medication, with reported incidence rates ranging from 2.5 to 40%. Despite its relatively low prevalence, hiccups pose substantial challenges for patients and healthcare providers. Complications associated with carbamazepine-induced hiccups include disruption of sleep, impaired social functioning, and decreased quality of life, underscoring the clinical significance of this side effect. Effective management strategies can be implemented through a multidisciplinary approach, including collaboration among neurologists, pharmacists, and other healthcare professionals. These may include dose adjustments, medication discontinuation, and adjunctive therapies such as diaphragmatic breathing exercises or acupuncture. Additionally, close monitoring for adverse effects and timely intervention are essential to mitigate the impact of hiccups on patient well-being. Essentially, carbamazepine-induced hiccups represent a clinically relevant phenomenon that warrants attention in the management of epilepsy. By recognizing the clinical manifestations, understanding the underlying pathophysiology, and implementing evidence-based management strategies, healthcare providers can optimize patient care and improve outcomes in this patient population.
摘要：
卡马西平,一种常用的抗癫痫药，已知会在一部分癫痫患者中诱发打嗝。虽然相对不常见，可能有重大的临床意义。这篇全面的综述探讨了卡马西平相关打嗝的临床和脑电图相关性，旨在增强对这种神经系统副作用的理解和管理。作者的综述综合了定性的流行病学数据，揭示卡马西平引起的打嗝发生在接受药物治疗的一部分患者中，报告的发病率为2.5％至40％。尽管患病率相对较低，打嗝给患者和医疗保健提供者带来了巨大的挑战。与卡马西平引起的打嗝相关的并发症包括睡眠中断，社会功能受损，生活质量下降，强调这种副作用的临床意义。有效的管理策略可以通过多学科方法来实施，包括神经学家之间的合作，药剂师,和其他医疗保健专业人员。这些可能包括剂量调整，停药,和辅助疗法，如膈呼吸练习或针灸。此外,密切监测不良反应和及时干预对于减轻打嗝对患者健康的影响至关重要.本质上,卡马西平诱发的打嗝是一种临床相关现象,在治疗癫痫时值得关注.通过识别临床表现，了解潜在的病理生理学，实施循证管理战略，医疗保健提供者可以优化患者护理并改善该患者人群的预后。
