PDF(Pubmed)
Abstract：
Porcine circoviruses (PCVs) are widely distributed in swine herds. PCV2, the significant swine pathogen, causes infections characterized by growth and development disorders, skin lesions, and respiratory distress. PCV3 has been circulating worldwide and can be associated with various clinical signs and disease developments. Wild boars are the main reservoir of these pathogens in wildlife and can create an alarming threat to pig farming. In Russia, three PCV2 genotypes (PCV2a, PCV2b, and PCV2d) were identified in pig farms. Additionally, PCV3 was observed in pig herds during the monitoring studies in the country. However, data considering the circulation of PCVs in herds of wild boars in Russia is scant. For this purpose, we performed PCR assays of the samples from 30 wild boars hunted in the Moscow Region of Russia in 2021-2023. The ratios of wild boars positive for PCV2, PCV3, or coinfected were 50, 10, and 13.3%, respectively. Additionally, we sequenced 15 PCV2 and four PCV3 complete genomes and conducted phylogenetic analysis, which divided PCV2 isolates into two groups: PCV2d and PCV2b. The study showed a high infection rate of PCV2 among wild boars, with PCV2d dominance. Simultaneously, PCV3 also circulates among wild boars. The obtained results can provide a basis for the development of preventive measures to support infection transmission risks between farm and wild animals.
摘要：
猪圆环病毒(PCV)在猪群中广泛分布。PCV2，重要的猪病原体，导致以生长和发育障碍为特征的感染，皮肤损伤,和呼吸窘迫。PCV3已在世界范围内流行，并且可能与各种临床体征和疾病发展有关。野猪是野生动物中这些病原体的主要宿主，可能对养猪业造成惊人的威胁。在俄罗斯,三种PCV2基因型(PCV2a，PCV2b,和PCV2d）在猪场中被鉴定。此外,在该国的监测研究中，在猪群中观察到PCV3。然而,考虑到俄罗斯野猪群中PCV流通的数据很少。为此,我们对2021-2023年在俄罗斯莫斯科地区狩猎的30头野猪的样本进行了PCR测定。PCV2、PCV3或合并感染的野猪阳性率分别为50％、10％和13.3％，分别。此外,我们对15个PCV2和4个PCV3完整基因组进行了测序，并进行了系统发育分析，将PCV2分离株分为两组：PCV2d和PCV2b。这项研究显示，野猪中PCV2的感染率很高，PCV2d占主导地位。同时,PCV3也在野猪中循环。获得的结果可为制定预防措施以支持农场和野生动物之间的感染传播风险提供依据。
