PDF(Pubmed)
Abstract：
UNASSIGNED: High dietary protein intake exacerbates proteinuria in individuals with diabetic kidney disease (DKD). However, studies on the impacts of low protein diet (LPD) on DKD have yielded conflicting results. Furthermore, patient compliance to continuous protein restriction is challenging.
UNASSIGNED: The current study aims to investigate the effects of intermittent protein restriction (IPR) on disease progression of DKD.
UNASSIGNED: Diabetic KK-Ay mice were used in this study. For the IPR treatment, three consecutive days of LPD were followed by four consecutive days of normal protein diet (NPD) within each week. For early intervention, mice received IPR before DKD onset. For late intervention, mice received IPR after DKD onset. In both experiments, age-matched mice fed continuous NPD served as the control group. Kidney morphology, structure and function of mice in different groups were examined.
UNASSIGNED: Intermittent protein restriction before DKD onset ameliorated pathological changes in kidney, including nephromegaly, glomerular hyperfiltration, tubular injuries and proteinuria, without improving glycemic control. Meanwhile, IPR initiated after DKD onset showed no renoprotective effects despite improved glucose homeostasis.
UNASSIGNED: Intermittent protein restriction before rather than after DKD onset protects kidneys, and the impacts of IPR on the kidneys are independent of glycemic control. IPR shows promise as an effective strategy for managing DKD and improving patient compliance.
UNASSIGNED: The current study aims to investigate the effects of intermittent protein restriction (IPR) on disease progression of DKD.
UNASSIGNED: Diabetic KK-Ay mice were used in this study. For the IPR treatment, three consecutive days of LPD were followed by four consecutive days of normal protein diet (NPD) within each week. For early intervention, mice received IPR before DKD onset. For late intervention, mice received IPR after DKD onset. In both experiments, age-matched mice fed continuous NPD served as the control group. Kidney morphology, structure and function of mice in different groups were examined.
UNASSIGNED: Intermittent protein restriction before DKD onset ameliorated pathological changes in kidney, including nephromegaly, glomerular hyperfiltration, tubular injuries and proteinuria, without improving glycemic control. Meanwhile, IPR initiated after DKD onset showed no renoprotective effects despite improved glucose homeostasis.
UNASSIGNED: Intermittent protein restriction before rather than after DKD onset protects kidneys, and the impacts of IPR on the kidneys are independent of glycemic control. IPR shows promise as an effective strategy for managing DKD and improving patient compliance.
摘要：
■高膳食蛋白质摄入会加剧糖尿病肾病（DKD）患者的蛋白尿。然而,关于低蛋白饮食（LPD）对DKD影响的研究得出了相互矛盾的结果。此外，患者对持续蛋白质限制的依从性具有挑战性.
■本研究旨在探讨间歇性蛋白限制（IPR）对DKD疾病进展的影响。
■糖尿病KK-Ay小鼠用于本研究。对于知识产权治疗，连续3天的LPD之后,每周内连续4天的正常蛋白饮食(NPD).对于早期干预，小鼠在DKD发病前接受IPR。对于后期干预，小鼠在DKD发病后接受IPR。在这两个实验中,以年龄匹配的连续NPD小鼠作为对照组。肾脏形态学,观察不同组小鼠的结构和功能。
■DKD发病前的间歇性蛋白限制可改善肾脏的病理变化，包括肾肥大症,肾小球滤过过度,肾小管损伤和蛋白尿，没有改善血糖控制。同时,尽管改善了葡萄糖稳态，但DKD发作后开始的IPR没有肾脏保护作用。
■在DKD发病之前而不是之后的间歇性蛋白质限制可以保护肾脏，IPR对肾脏的影响与血糖控制无关。IPR有望成为管理DKD和改善患者依从性的有效策略。
■本研究旨在探讨间歇性蛋白限制（IPR）对DKD疾病进展的影响。
■糖尿病KK-Ay小鼠用于本研究。对于知识产权治疗，连续3天的LPD之后,每周内连续4天的正常蛋白饮食(NPD).对于早期干预，小鼠在DKD发病前接受IPR。对于后期干预，小鼠在DKD发病后接受IPR。在这两个实验中,以年龄匹配的连续NPD小鼠作为对照组。肾脏形态学,观察不同组小鼠的结构和功能。
■DKD发病前的间歇性蛋白限制可改善肾脏的病理变化，包括肾肥大症,肾小球滤过过度,肾小管损伤和蛋白尿，没有改善血糖控制。同时,尽管改善了葡萄糖稳态，但DKD发作后开始的IPR没有肾脏保护作用。
■在DKD发病之前而不是之后的间歇性蛋白质限制可以保护肾脏，IPR对肾脏的影响与血糖控制无关。IPR有望成为管理DKD和改善患者依从性的有效策略。
