PDF(Pubmed)
Abstract：
UNASSIGNED: Current observational investigations hint at a potential linkage between ankylosing spondylitis and cardiovascular wellness. However, the nature of this causality remains to be elucidated. Consequently, this study is designed to evaluate the causal interconnection between ankylosing spondylitis and cardiovascular-related conditions utilizing a bidirectional two-sample Mendelian Randomization (MR) methodology.
UNASSIGNED: In this study, we conducted Mendelian randomization (MR) analyses using genome-wide association study (GWAS) data. The fixed-effects inverse variance weighted (IVW) model was used as the primary analysis method, and MR-Egger regression and the weighted median method were employed as supplementary approaches. Horizontal pleiotropy and heterogeneity were evaluated using various statistical tests, including MR-PRESSO global test, MR-Egger intercept, and Cochran\'s Q test.
UNASSIGNED: The MR result demonstrated an increased risk of heart failure in individuals with ankylosing spondylitis (OR: 1.0132, 95% CI = 1.0043-1.0221, p = 0.003). The MR analysis results did not demonstrate a causal relationship between ankylosing spondylitis and other cardiovascular diseases, such as atrial fibrillation, coronary artery disease, ischemic stroke, myocardial infarction, and valvular heart disease (all p > 0.05). No evidence of reverse causality was found between ankylosing spondylitis and mentioned cardiovascular diseases in reverse MR analyses. Sensitivity analysis verified the reliability of the results.
UNASSIGNED: Our MR study indicates a relationship between ankylosing spondylitis and an increased risk of heart failure. Further research is needed to confirm these findings and elucidate the underlying mechanisms involved.
UNASSIGNED: In this study, we conducted Mendelian randomization (MR) analyses using genome-wide association study (GWAS) data. The fixed-effects inverse variance weighted (IVW) model was used as the primary analysis method, and MR-Egger regression and the weighted median method were employed as supplementary approaches. Horizontal pleiotropy and heterogeneity were evaluated using various statistical tests, including MR-PRESSO global test, MR-Egger intercept, and Cochran\'s Q test.
UNASSIGNED: The MR result demonstrated an increased risk of heart failure in individuals with ankylosing spondylitis (OR: 1.0132, 95% CI = 1.0043-1.0221, p = 0.003). The MR analysis results did not demonstrate a causal relationship between ankylosing spondylitis and other cardiovascular diseases, such as atrial fibrillation, coronary artery disease, ischemic stroke, myocardial infarction, and valvular heart disease (all p > 0.05). No evidence of reverse causality was found between ankylosing spondylitis and mentioned cardiovascular diseases in reverse MR analyses. Sensitivity analysis verified the reliability of the results.
UNASSIGNED: Our MR study indicates a relationship between ankylosing spondylitis and an increased risk of heart failure. Further research is needed to confirm these findings and elucidate the underlying mechanisms involved.
摘要：
■目前的观察性研究提示强直性脊柱炎和心血管健康之间存在潜在的联系。然而,这种因果关系的性质还有待阐明。因此,本研究旨在利用双向双样本孟德尔随机化(MR)方法学评估强直性脊柱炎与心血管相关疾病之间的因果关系.
■在这项研究中，我们使用全基因组关联研究(GWAS)数据进行了孟德尔随机化(MR)分析.采用固定效应逆方差加权(IVW)模型作为主要分析方法，MR-Egger回归和加权中位数法作为补充方法。使用各种统计检验评估水平多效性和异质性，包括MR-PRESSO全球测试，MR-Egger截获,和Cochran的Q测试。
■MR结果显示，强直性脊柱炎患者心力衰竭风险增加（OR：1.0132，95%CI=1.0043-1.0221，p=0.003）。MR分析结果未显示强直性脊柱炎与其他心血管疾病之间的因果关系。比如心房颤动,冠状动脉疾病,缺血性卒中,心肌梗塞,和心脏瓣膜病(均p>0.05)。在反向MR分析中，没有发现强直性脊柱炎与提到的心血管疾病之间存在反向因果关系的证据。灵敏度分析验证了结果的可靠性。
■我们的MR研究表明强直性脊柱炎与心力衰竭风险增加之间存在关系。需要进一步的研究来证实这些发现并阐明所涉及的潜在机制。
■在这项研究中，我们使用全基因组关联研究(GWAS)数据进行了孟德尔随机化(MR)分析.采用固定效应逆方差加权(IVW)模型作为主要分析方法，MR-Egger回归和加权中位数法作为补充方法。使用各种统计检验评估水平多效性和异质性，包括MR-PRESSO全球测试，MR-Egger截获,和Cochran的Q测试。
■MR结果显示，强直性脊柱炎患者心力衰竭风险增加（OR：1.0132，95%CI=1.0043-1.0221，p=0.003）。MR分析结果未显示强直性脊柱炎与其他心血管疾病之间的因果关系。比如心房颤动,冠状动脉疾病,缺血性卒中,心肌梗塞,和心脏瓣膜病(均p>0.05)。在反向MR分析中，没有发现强直性脊柱炎与提到的心血管疾病之间存在反向因果关系的证据。灵敏度分析验证了结果的可靠性。
■我们的MR研究表明强直性脊柱炎与心力衰竭风险增加之间存在关系。需要进一步的研究来证实这些发现并阐明所涉及的潜在机制。
