PDF(Pubmed)
Abstract：
UNASSIGNED: Accumulating evidence suggests that patients with ankylosing spondylitis (AS) have an elevated risk for cardiovascular disease (CVD) and cardiovascular death, however, whether AS has causal effects on the risk of CVD is unclear.Two-sample Mendelian randomization (MR) was utilizedto examine the probable causal link between them.
UNASSIGNED: Summary statistics from publicly released genome-wide association studies (GWAS) was used to perform MR analyses. Genetically predicted AS was selected as the exposure variable from published GWAS meta-analyses. CVD was adopted as the outcome variable. The inverse variant weighted method was employed to obtain the casual estimates. The robustness of the results was also examined by evaluating the pleiotropy and heterogeneity of single-nucleotide polymorphisms.
UNASSIGNED: According to MR analyses, genetic susceptibility to AS was associated with a high risk of heart failure and ischemic stroke, while negativelygenetic susceptibility was found between AS and peripheral atherosclerosis. No statistical relationship was found between AS and venous thromboembolism, atrial fibrillation, coronary atherosclerosis, and valvular heart disease. Sensitivity analysis showed no evidence of horizontal pleiotropy or heterogeneity.
UNASSIGNED: The present study suggests that AS exerts causal effects on the risk of CVD, including heart failure, ischemic stroke, and peripheral atherosclerosis.
UNASSIGNED: Summary statistics from publicly released genome-wide association studies (GWAS) was used to perform MR analyses. Genetically predicted AS was selected as the exposure variable from published GWAS meta-analyses. CVD was adopted as the outcome variable. The inverse variant weighted method was employed to obtain the casual estimates. The robustness of the results was also examined by evaluating the pleiotropy and heterogeneity of single-nucleotide polymorphisms.
UNASSIGNED: According to MR analyses, genetic susceptibility to AS was associated with a high risk of heart failure and ischemic stroke, while negativelygenetic susceptibility was found between AS and peripheral atherosclerosis. No statistical relationship was found between AS and venous thromboembolism, atrial fibrillation, coronary atherosclerosis, and valvular heart disease. Sensitivity analysis showed no evidence of horizontal pleiotropy or heterogeneity.
UNASSIGNED: The present study suggests that AS exerts causal effects on the risk of CVD, including heart failure, ischemic stroke, and peripheral atherosclerosis.
摘要：
■越来越多的证据表明，强直性脊柱炎（AS）患者心血管疾病（CVD）和心血管死亡的风险升高，然而,目前尚不清楚AS是否对CVD风险有因果关系.利用两个样本孟德尔随机化（MR）来检查它们之间可能的因果关系。
■使用公开发布的全基因组关联研究（GWAS）的汇总统计数据进行MR分析。从已发表的GWAS荟萃分析中选择遗传预测的AS作为暴露变量。采用CVD作为结果变量。采用逆变量加权方法获得临时估计。还通过评估单核苷酸多态性的多效性和异质性来检查结果的稳健性。
■根据MR分析，AS的遗传易感性与心力衰竭和缺血性卒中的高风险相关，而在AS和外周动脉粥样硬化之间发现了负遗传易感性。AS与静脉血栓栓塞症之间无统计学关系,心房颤动,冠状动脉粥样硬化,和心脏瓣膜病.敏感性分析显示没有水平多效性或异质性的证据。
■本研究表明，AS对心血管疾病的风险有因果关系，包括心力衰竭,缺血性卒中,和外周动脉粥样硬化。
■使用公开发布的全基因组关联研究（GWAS）的汇总统计数据进行MR分析。从已发表的GWAS荟萃分析中选择遗传预测的AS作为暴露变量。采用CVD作为结果变量。采用逆变量加权方法获得临时估计。还通过评估单核苷酸多态性的多效性和异质性来检查结果的稳健性。
■根据MR分析，AS的遗传易感性与心力衰竭和缺血性卒中的高风险相关，而在AS和外周动脉粥样硬化之间发现了负遗传易感性。AS与静脉血栓栓塞症之间无统计学关系,心房颤动,冠状动脉粥样硬化,和心脏瓣膜病.敏感性分析显示没有水平多效性或异质性的证据。
■本研究表明，AS对心血管疾病的风险有因果关系，包括心力衰竭,缺血性卒中,和外周动脉粥样硬化。
