PDF(Pubmed)
Abstract：
The Coronavirus Disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has incurred devastating human and economic losses. Vaccination remains the most effective approach for controlling the COVID-19 pandemic. Nonetheless, the sustained evolution of SARS-CoV-2 variants has provoked concerns among the scientific community regarding the development of next-generation COVID-19 vaccines. Among these, given their safety, immunogenicity, and flexibility to display varied and native epitopes, virus-like particle (VLP)-based vaccines represent one of the most promising next-generation vaccines. In this review, we summarize the advantages and characteristics of VLP platforms, strategies for antigen display, and current clinical trial progress of SARS-CoV-2 vaccines based on VLP platforms. Importantly, the experience and lessons learned from the development of SARS-CoV-2 VLP vaccines provide insights into the development of strategies based on VLP vaccines to prevent future coronavirus pandemics and other epidemics.
摘要：
2019年冠状病毒病（COVID-19）大流行，由严重急性呼吸道综合症冠状病毒2（SARS-CoV-2）引起，造成了毁灭性的人员和经济损失。疫苗接种仍然是控制COVID-19大流行的最有效方法。尽管如此，SARS-CoV-2变种的持续进化引起了科学界对下一代COVID-19疫苗开发的担忧。其中,考虑到他们的安全,免疫原性,以及展示各种天然表位的灵活性，基于病毒样颗粒（VLP）的疫苗是最有前途的下一代疫苗之一。在这次审查中,我们总结了VLP平台的优势和特点，抗原展示策略，和目前基于VLP平台的SARS-CoV-2疫苗的临床试验进展。重要的是,SARS-CoV-2VLP疫苗开发的经验和教训为制定基于VLP疫苗的预防未来冠状病毒大流行和其他流行病的策略提供了见解。
