PDF(Pubmed)
Abstract：
A scoping review of 45 peer-reviewed manuscripts involving intraocular pressure (IOP) change and concurrent optical coherence tomography angiography (OCTA) assessments was performed to aggregate knowledge, summarize major findings, and identify gaps in literature and methodology relating to the effect of IOP change on OCTA. Articles were identified through PubMed/Medline, Google Scholar, Cochrane, Web of Science, and article reference lists. A total of 838 results were identified, and 45 articles met the inclusion and exclusion criteria for detailed analysis. OCTA metrics including vessel density (VD), perfusion density, and flow density of the superficial capillary plexus and the radial peripapillary capillaries were analyzed in relation to relative temporal IOP changes. Overall, IOP changes were found to affect superficial vascular plexus (VD) measurements on OCTA, especially when IOP elevated above the physiologic normal range (10-21 mmHg). No significant association was found between diurnal IOP variation and OCTA metrics. Cataract surgery improved the whole-image signal strength and VD regardless of changes in IOP. Beta-blockers were associated with paradoxically reduced vessel density in normal tension glaucoma patients in two studies. Although glaucoma surgical intervention studies were inconsistent and limited by scan quality and low sample sizes, patients requiring glaucoma surgery exhibited attenuated postoperative superficial VD recovery despite significant IOP reductions with surgical intervention. In addition to ensuring near-perfect signal strength with minimal media opacities and controlling for high myopia, central corneal thickness, and the presence of retinopathy, clinicians should consider the statistically significant impact of IOP on OCTA metrics when interpreting results.
摘要：
对45份涉及眼内压（IOP）变化和并发光学相干断层扫描血管造影（OCTA）评估的同行评审手稿进行范围审查，以汇总知识。总结主要发现，并确定与IOP变化对OCTA影响相关的文献和方法的差距。文章是通过PubMed/Medline确定的，谷歌学者，科克伦,WebofScience,和文章参考列表。共确定了838个结果，45篇文章符合纳入和排除标准进行详细分析。OCTA指标，包括血管密度(VD)，灌注密度,分析了浅表毛细血管丛和放射状乳头周围毛细血管的流量密度与相对时间眼压变化的关系。总的来说,发现IOP变化会影响OCTA的浅表血管丛（VD）测量值，特别是当眼压升高到生理正常范围（10-21mmHg）以上时。在昼夜IOP变化与OCTA指标之间没有发现显着关联。白内障手术改善了整个图像信号强度和VD，而与IOP的变化无关。在两项研究中，β受体阻滞剂与正常眼压性青光眼患者的血管密度降低有关。尽管青光眼手术干预研究不一致，并且受到扫描质量和低样本量的限制，需要青光眼手术的患者术后浅表VD恢复减弱,尽管手术干预后IOP显著降低.除了确保近乎完美的信号强度与最小的媒体混浊和控制高度近视，中央角膜厚度,视网膜病变的存在，临床医师在解释结果时应考虑IOP对OCTA指标的统计学显著影响.
