PDF(Pubmed)
Abstract：
UNASSIGNED: Suicidal ideation and behavior (SIB) are serious problems in people with schizophrenia spectrum disorders (SSD). Nevertheless, relatively little is known about the circuitry underlying SIB in SSD. Recently, we showed that elevated emotional impulsivity (urgency) was associated with SIB in SSD. Here we examined brain activity in people with SSD and elevated SIB.
UNASSIGNED: We tested 16 people with SSD who had low SIB and 14 people with high SIB on a task in which emotion regulation in response to affective pictures was implicitly manipulated using spoken sentences. Thus, there were neutral pictures preceded by neutral statements (NeutNeut condition), as well as negative pictures preceded by either negative (NegNeg) or neutral (NeutNeg) statements. After each picture, participants rated how unpleasant each picture was for them. The latter two conditions were compared to the NeutNeut condition. We compared the emotion-regulated condition (NeutNeg) to the unregulated condition (NeutNeut). Statistics were threshold using threshold free cluster enhancement (TFCE).
UNASSIGNED: People in the low SIB group showed higher activation in this contrast in medial frontal gyrus, right rostral anterior cingulate, bilateral superior frontal gyrus/DLPFC, and right middle cingulate gyrus, as well as right superior temporal gyrus.
UNASSIGNED: This study provides clues to the neural basis of SIB in SSD as well as underlying mechanisms.
UNASSIGNED: We tested 16 people with SSD who had low SIB and 14 people with high SIB on a task in which emotion regulation in response to affective pictures was implicitly manipulated using spoken sentences. Thus, there were neutral pictures preceded by neutral statements (NeutNeut condition), as well as negative pictures preceded by either negative (NegNeg) or neutral (NeutNeg) statements. After each picture, participants rated how unpleasant each picture was for them. The latter two conditions were compared to the NeutNeut condition. We compared the emotion-regulated condition (NeutNeg) to the unregulated condition (NeutNeut). Statistics were threshold using threshold free cluster enhancement (TFCE).
UNASSIGNED: People in the low SIB group showed higher activation in this contrast in medial frontal gyrus, right rostral anterior cingulate, bilateral superior frontal gyrus/DLPFC, and right middle cingulate gyrus, as well as right superior temporal gyrus.
UNASSIGNED: This study provides clues to the neural basis of SIB in SSD as well as underlying mechanisms.
摘要：
■自杀意念和行为（SIB）是精神分裂症谱系障碍（SSD）患者的严重问题。然而，对SSD中SIB底层的电路知之甚少。最近,我们表明，在SSD中，情绪冲动性（紧迫性）升高与SIB相关。在这里，我们检查了患有SSD和SIB升高的人的大脑活动。
■我们在一项任务中测试了16名SIB较低的SSD患者和14名SIB较高的SSD患者，在这项任务中，使用口语句子隐式地操纵了对情感图片的情绪调节。因此，在中性图片之前有中性声明(NeutNeut条件)，以及之前有否定（NegNeg）或中性（NeutNeg）声明的负面图片。在每张照片之后，参与者评估每张照片对他们来说有多不愉快。将后两个条件与NeutNeut条件进行比较。我们将情绪调节状况（NeutNeg）与不调节状况（NeutNeut）进行了比较。使用无阈值聚类增强（TFCE）进行阈值统计。
■低SIB组的人在内侧额回的这种对比中显示出更高的激活，右首前扣带回,双侧额上回/DLPFC，和右中间扣带回，以及右颞上回。
■这项研究为SSD中SIB的神经基础以及潜在机制提供线索。
■我们在一项任务中测试了16名SIB较低的SSD患者和14名SIB较高的SSD患者，在这项任务中，使用口语句子隐式地操纵了对情感图片的情绪调节。因此，在中性图片之前有中性声明(NeutNeut条件)，以及之前有否定（NegNeg）或中性（NeutNeg）声明的负面图片。在每张照片之后，参与者评估每张照片对他们来说有多不愉快。将后两个条件与NeutNeut条件进行比较。我们将情绪调节状况（NeutNeg）与不调节状况（NeutNeut）进行了比较。使用无阈值聚类增强（TFCE）进行阈值统计。
■低SIB组的人在内侧额回的这种对比中显示出更高的激活，右首前扣带回,双侧额上回/DLPFC，和右中间扣带回，以及右颞上回。
■这项研究为SSD中SIB的神经基础以及潜在机制提供线索。
