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Abstract：
UNASSIGNED: To identify the correlation between thrombosis and atherosclerosis in systemic lupus erythematosus (SLE) patients with antiphospholipid antibodies (aPLs) (SLE/aPLs) through high-resolution magnetic resonance imaging (HR-MRI) of the carotid artery.
UNASSIGNED: A single-center, cross-sectional study was conducted. We collected consecutive patients with SLE/aPLs and healthy controls who underwent carotid HR-MRI examinations. The morphometric characteristics of the common carotid artery (CCA), internal carotid artery (ICA), external carotid artery (ECA), and carotid bulb (Sinus) were measured, and the differences in morphometric parameters between different groups were analyzed.
UNASSIGNED: A total of 144 carotid arteries were analyzed. Compared with the control group, the wall area, wall thickness (WT and WTmax), and normalized wall index of CCA, ICA, ECA, and Sinus were increased in patients with SLE/aPLs, and the total vascular area (TVA) of CCA, ICA, and Sinus, and the bifurcation angle (BIFA) of ICA-ECA were also increased. A negative lupus anticoagulant (LAC) (with or without positive anticardiolipin antibody (aCL) or anti-β2glycoprotein antibody (aβ2GPI)) contributed to illustrating lower increased TVA and thickened vessel walls of CCA and ICA in SLE/aPLs patients without thrombotic events. Logistic regression analysis showed that WTmaxSinus and WTmaxGlobal were independent risk factors for thrombotic events in SLE/aPLs patients. The receiver operator characteristic curve showed that the cut-off value of WTmaxSinus was 2.855 mm, and WTmaxGlobal was 3.370 mm.
UNASSIGNED: HR-MRI ensures the complete and accurate measurement of carotid morphometric parameters. Compared with the control group, the carotid artery in patients with SLE/aPLs is mainly characterized by diffusely thickened vessel walls, and the patients with thrombotic events showed additional higher vascular area of CCA and ICA, and BIFA of ICA-ECA without significant change in lumen area. The carotid arteries of SLE/aPLs patients with thrombotic events exhibited significant vessel wall thickening in all segments except ECA compared to those without thrombotic events. LAC-negative and non-thrombotic events distinguish relatively early atherosclerosis in the carotid arteries in patients with SLE/aPLs. Patients with SLE/aPLs that possess circumscribed thickened carotid vessel walls (>3.370 mm), particularly thickened at the Sinus (>2.855 mm), may require management strategies for the risk of thrombotic events.
UNASSIGNED: A single-center, cross-sectional study was conducted. We collected consecutive patients with SLE/aPLs and healthy controls who underwent carotid HR-MRI examinations. The morphometric characteristics of the common carotid artery (CCA), internal carotid artery (ICA), external carotid artery (ECA), and carotid bulb (Sinus) were measured, and the differences in morphometric parameters between different groups were analyzed.
UNASSIGNED: A total of 144 carotid arteries were analyzed. Compared with the control group, the wall area, wall thickness (WT and WTmax), and normalized wall index of CCA, ICA, ECA, and Sinus were increased in patients with SLE/aPLs, and the total vascular area (TVA) of CCA, ICA, and Sinus, and the bifurcation angle (BIFA) of ICA-ECA were also increased. A negative lupus anticoagulant (LAC) (with or without positive anticardiolipin antibody (aCL) or anti-β2glycoprotein antibody (aβ2GPI)) contributed to illustrating lower increased TVA and thickened vessel walls of CCA and ICA in SLE/aPLs patients without thrombotic events. Logistic regression analysis showed that WTmaxSinus and WTmaxGlobal were independent risk factors for thrombotic events in SLE/aPLs patients. The receiver operator characteristic curve showed that the cut-off value of WTmaxSinus was 2.855 mm, and WTmaxGlobal was 3.370 mm.
UNASSIGNED: HR-MRI ensures the complete and accurate measurement of carotid morphometric parameters. Compared with the control group, the carotid artery in patients with SLE/aPLs is mainly characterized by diffusely thickened vessel walls, and the patients with thrombotic events showed additional higher vascular area of CCA and ICA, and BIFA of ICA-ECA without significant change in lumen area. The carotid arteries of SLE/aPLs patients with thrombotic events exhibited significant vessel wall thickening in all segments except ECA compared to those without thrombotic events. LAC-negative and non-thrombotic events distinguish relatively early atherosclerosis in the carotid arteries in patients with SLE/aPLs. Patients with SLE/aPLs that possess circumscribed thickened carotid vessel walls (>3.370 mm), particularly thickened at the Sinus (>2.855 mm), may require management strategies for the risk of thrombotic events.
摘要：
■通过颈动脉的高分辨率磁共振成像（HR-MRI），确定系统性红斑狼疮（SLE）患者抗磷脂抗体（aPLs）（SLE/aPLs）的血栓形成与动脉粥样硬化之间的相关性。
■单中心，进行了横断面研究。我们收集了连续的SLE/aPLs患者和接受颈动脉HR-MRI检查的健康对照。颈总动脉（CCA）的形态特征，颈内动脉(ICA),颈外动脉(ECA),测量颈动脉球（窦），并分析不同组间形态测量参数的差异。
■共分析了144条颈动脉。与对照组相比,墙壁区域,壁厚（WT和WTmax），和CCA的归一化壁指数，ICA,ECA,SLE/aPLs患者的窦增加，和CCA的总血管面积（TVA），ICA,和窦,ICA-ECA的分叉角（BIFA）也增加。狼疮抗凝物（LAC）阴性（有或没有抗心磷脂抗体（aCL）或抗β2糖蛋白抗体（aβ2GPI）阳性）有助于说明在无血栓形成的SLE/aPLs患者中TVA增加较低，CCA和ICA的血管壁增厚事件。Logistic回归分析显示WTmaxSinus和WTmaxGlobal是SLE/aPLs患者发生血栓事件的独立危险因素。接收器操作特性曲线显示WTmaxSinus的截止值为2.855mm,WTmaxGlobal为3.370毫米。
■HR-MRI可确保完整，准确地测量颈动脉形态参数。与对照组相比,SLE/aPLs患者的颈动脉主要表现为血管壁弥漫性增厚，有血栓性事件的患者表现出更高的CCA和ICA血管面积，ICA-ECA的BIFA和管腔面积无明显变化。有血栓事件的SLE/aPLs患者的颈动脉与无血栓事件的患者相比，除ECA外，所有节段均表现出明显的血管壁增厚。LAC阴性和非血栓性事件可区分SLE/aPLs患者颈动脉相对早期的动脉粥样硬化。患有SLE/aPLs的患者，其颈动脉血管壁受限增厚（>3.370mm），特别是在窦增厚（>2.855毫米），可能需要针对血栓事件风险的管理策略。
■单中心，进行了横断面研究。我们收集了连续的SLE/aPLs患者和接受颈动脉HR-MRI检查的健康对照。颈总动脉（CCA）的形态特征，颈内动脉(ICA),颈外动脉(ECA),测量颈动脉球（窦），并分析不同组间形态测量参数的差异。
■共分析了144条颈动脉。与对照组相比,墙壁区域,壁厚（WT和WTmax），和CCA的归一化壁指数，ICA,ECA,SLE/aPLs患者的窦增加，和CCA的总血管面积（TVA），ICA,和窦,ICA-ECA的分叉角（BIFA）也增加。狼疮抗凝物（LAC）阴性（有或没有抗心磷脂抗体（aCL）或抗β2糖蛋白抗体（aβ2GPI）阳性）有助于说明在无血栓形成的SLE/aPLs患者中TVA增加较低，CCA和ICA的血管壁增厚事件。Logistic回归分析显示WTmaxSinus和WTmaxGlobal是SLE/aPLs患者发生血栓事件的独立危险因素。接收器操作特性曲线显示WTmaxSinus的截止值为2.855mm,WTmaxGlobal为3.370毫米。
■HR-MRI可确保完整，准确地测量颈动脉形态参数。与对照组相比,SLE/aPLs患者的颈动脉主要表现为血管壁弥漫性增厚，有血栓性事件的患者表现出更高的CCA和ICA血管面积，ICA-ECA的BIFA和管腔面积无明显变化。有血栓事件的SLE/aPLs患者的颈动脉与无血栓事件的患者相比，除ECA外，所有节段均表现出明显的血管壁增厚。LAC阴性和非血栓性事件可区分SLE/aPLs患者颈动脉相对早期的动脉粥样硬化。患有SLE/aPLs的患者，其颈动脉血管壁受限增厚（>3.370mm），特别是在窦增厚（>2.855毫米），可能需要针对血栓事件风险的管理策略。
