PDF(Pubmed)
Abstract：
UNASSIGNED: We have shown that genetic factors associating with motor progression of Parkinson\'s disease (PD), but their roles in cognitive function is poorly understood. One reason is that while cognitive performance in PD can be evaluated by various cognitive scales, there is no definitive guide indicating which tool performs better.
UNASSIGNED: Data were obtained from the Parkinson\'s Progression Markers Initiative, where cognitive performance was assessed using five cognitive screening tools, including Symbol Digit Modalities Test (SDMT), Montreal Cognitive Assessment, Benton Judgment of Line Orientation, Modified Semantic Fluency Test, and Letter Number Sequencing Test, at baseline and subsequent annual follow-up visit for 5 years. Genetic data including ApoE and other PD risk genetic information were also obtained. We used SPSS-receiver operating characteristic and ANOVA repeated measures to evaluate which cognitive assessment is the best reflecting cognitive performance in PD at early stage and over time. Logistic regression analyses were used to determine the genetic associations with the rapidity of cognitive decline in PD.
UNASSIGNED: SDMT performed better in detecting mild cognitive impairment at baseline (AUC = 0.763), and SDMT was the only tool showing a steady cognitive decline during longitudinal observation. Multigenetic factors significantly associated with cognitive impairment at early stage of the disease (AUC = 0.950) with IP6K2 rs12497850 more evident, and a significantly faster decline (AUC = 0.831) within 5 years after motor onset, particularly in those carrying FGF20 rs591323.
UNASSIGNED: SDMT is a preferable cognitive assessment tool for PD and genetic factors synergistically contribute to the cognitive dysfunction in PD.
UNASSIGNED: Data were obtained from the Parkinson\'s Progression Markers Initiative, where cognitive performance was assessed using five cognitive screening tools, including Symbol Digit Modalities Test (SDMT), Montreal Cognitive Assessment, Benton Judgment of Line Orientation, Modified Semantic Fluency Test, and Letter Number Sequencing Test, at baseline and subsequent annual follow-up visit for 5 years. Genetic data including ApoE and other PD risk genetic information were also obtained. We used SPSS-receiver operating characteristic and ANOVA repeated measures to evaluate which cognitive assessment is the best reflecting cognitive performance in PD at early stage and over time. Logistic regression analyses were used to determine the genetic associations with the rapidity of cognitive decline in PD.
UNASSIGNED: SDMT performed better in detecting mild cognitive impairment at baseline (AUC = 0.763), and SDMT was the only tool showing a steady cognitive decline during longitudinal observation. Multigenetic factors significantly associated with cognitive impairment at early stage of the disease (AUC = 0.950) with IP6K2 rs12497850 more evident, and a significantly faster decline (AUC = 0.831) within 5 years after motor onset, particularly in those carrying FGF20 rs591323.
UNASSIGNED: SDMT is a preferable cognitive assessment tool for PD and genetic factors synergistically contribute to the cognitive dysfunction in PD.
摘要：
■我们已经证明遗传因素与帕金森病（PD）的运动进展有关，但人们对它们在认知功能中的作用知之甚少。一个原因是，虽然PD的认知表现可以通过各种认知量表来评估，没有明确的指南表明哪个工具性能更好。
■数据来自帕金森进展标志物倡议，使用五种认知筛查工具评估认知表现，包括符号数字模式测试(SDMT)，蒙特利尔认知评估，Benton对线路方向的判断,改进的语义流畅性测试，和字母数字排序测试，在基线和随后的5年年度随访时.还获得了包括ApoE和其他PD风险遗传信息的遗传数据。我们使用SPSS接收器工作特性和ANOVA重复测量来评估哪种认知评估在早期和随着时间的推移最能反映PD的认知表现。Logistic回归分析用于确定与PD认知下降速度的遗传关联。
■SDMT在基线时检测轻度认知障碍方面表现更好（AUC=0.763），SDMT是唯一在纵向观察过程中显示出稳定认知能力下降的工具。多遗传因素与疾病早期认知障碍显著相关（AUC=0.950），IP6K2rs1249850更为明显，并且在运动发作后5年内明显更快的下降（AUC=0.831），特别是那些携带FGF20rs591323。
■SDMT是PD的优选认知评估工具，遗传因素协同作用于PD的认知功能障碍。
■数据来自帕金森进展标志物倡议，使用五种认知筛查工具评估认知表现，包括符号数字模式测试(SDMT)，蒙特利尔认知评估，Benton对线路方向的判断,改进的语义流畅性测试，和字母数字排序测试，在基线和随后的5年年度随访时.还获得了包括ApoE和其他PD风险遗传信息的遗传数据。我们使用SPSS接收器工作特性和ANOVA重复测量来评估哪种认知评估在早期和随着时间的推移最能反映PD的认知表现。Logistic回归分析用于确定与PD认知下降速度的遗传关联。
■SDMT在基线时检测轻度认知障碍方面表现更好（AUC=0.763），SDMT是唯一在纵向观察过程中显示出稳定认知能力下降的工具。多遗传因素与疾病早期认知障碍显著相关（AUC=0.950），IP6K2rs1249850更为明显，并且在运动发作后5年内明显更快的下降（AUC=0.831），特别是那些携带FGF20rs591323。
■SDMT是PD的优选认知评估工具，遗传因素协同作用于PD的认知功能障碍。
