PDF(Pubmed)
Abstract：
The development of novel drugs from basic science to clinical practice requires several years, much effort, and cost. Drug repurposing can promote the utilization of clinical drugs in cancer therapy. Recent studies have shown the potential effects of lomitapide on treating malignancies, which is currently used for the treatment of familial hypercholesterolemia. We systematically review possible functions and mechanisms of lomitapide as an anti-tumor compound, regarding the aspects of apoptosis, autophagy, and metabolism of tumor cells, to support repurposing lomitapide for the clinical treatment of tumors.
摘要：
新药从基础科学发展到临床实践需要数年时间,很多努力,和成本。药物再利用可以促进临床药物在肿瘤治疗中的应用。最近的研究表明，洛米他必特治疗恶性肿瘤的潜在作用，目前用于治疗家族性高胆固醇血症。我们系统地回顾了lomitapide作为抗肿瘤化合物的可能功能和机制。关于凋亡的方面，自噬,和肿瘤细胞的代谢，支持将洛米他必特用于肿瘤的临床治疗。
