PDF(Pubmed)
Abstract：
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is a critical innate immune pathway primarily due to its vital DNA sensing mechanism in pathogen defence. Recent research advances have shown that excessive activation or damage to the cGAS-STING pathway can exacerbate chronic inflammatory responses, playing a significant role in metabolic dysfunction and aging, leading to the development of related diseases such as obesity, osteoporosis, and neurodegenerative diseases. This article reviews the structure and biological functions of the cGAS-STING signaling pathway and discusses in detail how this pathway regulates the occurrence and development of metabolic and age-related diseases. Additionally, this article introduces potential small molecule drugs targeting cGAS and STING, aiming to provide new research perspectives for studying the pathogenesis and treatment of metabolic-related diseases.
摘要：
干扰素基因的环GMP-AMP合酶（cGAS）-刺激物（STING）途径是关键的先天性免疫途径，主要是由于其在病原体防御中的重要DNA传感机制。最近的研究进展表明，cGAS-STING通路的过度激活或损伤可加剧慢性炎症反应，在代谢功能障碍和衰老中起重要作用，导致肥胖等相关疾病的发展，骨质疏松,和神经退行性疾病。本文综述了cGAS-STING信号通路的结构和生物学功能，并详细讨论了该通路如何调控代谢和年龄相关疾病的发生发展。此外,本文介绍了靶向cGAS和STING的潜在小分子药物，旨在为研究代谢相关疾病的发病机制和治疗提供新的研究视角。
