PDF(Pubmed)
Abstract：
In response to invading parasites, one of the principal arms of innate immunity is oxidative stress, caused by reactive oxygen species (ROS). However, oxidative stresses play dual functions in the disease, whereby free radicals promote pathogen removal, but they can also trigger inflammation, resulting in tissue injuries. A growing body of evidence has strongly supported the notion that nuclear factor erythroid 2-related factor 2 (NRF) signaling is one of the main antioxidant pathways to combat this oxidative burst against parasites. Given the important role of NRF2 in oxidative stress, in this review, we investigate the activation mechanism of the NRF2 antioxidant pathway in different parasitic diseases, such as malaria, leishmaniasis, trypanosomiasis, toxoplasmosis, schistosomiasis, entamoebiasis, and trichinosis.
摘要：
为了应对入侵的寄生虫，先天免疫的主要分支之一是氧化应激，由活性氧（ROS）引起。然而,氧化应激在疾病中发挥双重功能，其中自由基促进病原体去除，但它们也能引发炎症，导致组织损伤。越来越多的证据强烈支持以下观点：核因子红系2相关因子2（NRF）信号传导是对抗这种针对寄生虫的氧化爆发的主要抗氧化途径之一。鉴于NRF2在氧化应激中的重要作用,在这次审查中,我们研究了NRF2抗氧化途径在不同寄生虫病中的激活机制,比如疟疾，利什曼病,锥虫病,弓形虫病,血吸虫病,内阿米巴病,还有旋毛虫病.
