PDF(Pubmed)
Abstract：
Aging and circadian rhythms have been connected for decades, but their molecular interaction has remained unknown, especially for cancers. In this situation, we summarized the current research actuality and problems in this field using the bibliometric analysis. Publications in the PubMed and Web of Science databases were retrieved. Overall, there is a rising trend in the publication volume regarding aging and circadian rhythms in the field of cancer. Researchers from USA, Germany, Italy, China and England have greater studies than others. Top three publication institutions are University of California System, UDICE-French Research Universities and University of Texas System. Current research hotspots include oxidative stress, breast cancer, melatonin, cell cycle, calorie restriction, prostate cancer and NF-KB. In conclusion, results generated by bibliometric analysis indicate that many approaches involve in the complex interactions between aging and circadian rhythm in cancer. These established and emerging research directions guide our exploration of the regulatory mechanisms of aging and circadian rhythms in cancer and provide a reference for developing new research avenues.
摘要：
衰老和昼夜节律已经联系了几十年，但是它们的分子相互作用仍然未知，尤其是癌症。在这种情况下,通过文献计量分析，总结了该领域的研究现状和存在的问题。检索了PubMed和WebofScience数据库中的出版物。总的来说,关于癌症领域的衰老和昼夜节律的出版物数量呈上升趋势。来自美国的研究人员,德国,意大利,中国和英国比其他国家有更多的研究。排名前三的出版机构是加州大学系统，UDICE-法国研究型大学和德克萨斯大学系统。目前的研究热点包括氧化应激，乳腺癌,褪黑激素,细胞周期,卡路里限制,前列腺癌和NF-KB。总之,文献计量分析的结果表明，许多方法涉及癌症衰老和昼夜节律之间的复杂相互作用。这些既定和新兴的研究方向指导我们探索癌症衰老和昼夜节律的调控机制，为开发新的研究途径提供参考。
