PDF(Pubmed)
Abstract：
Eating disorders are severe psychiatric illnesses that are associated with high mortality. Research has identified environmental, psychological, and biological risk factors that could contribute to the psychopathology of eating disorders. Nevertheless, the patterns of self-starvation, binge eating, and purging behaviors are difficult to reconcile with the typical mechanisms that regulate appetite, hunger, and satiety. Here, the authors present a neuroscience and human brain imaging-based model to help explain the detrimental and often persistent behavioral patterns seen in individuals with eating disorders and why it is so difficult to overcome them. This model incorporates individual motivations to change eating, fear conditioning, biological adaptations of the brain and body, and the development of a vicious cycle that drives the individual to perpetuate those behaviors. This knowledge helps to explain these illnesses to patients and their families, and to develop more effective treatments, including biological interventions.
摘要：
饮食失调是与高死亡率相关的严重精神疾病。研究已经确定了环境，心理,以及可能导致饮食失调的精神病理学的生物学风险因素。然而，自我饥饿的模式，暴饮暴食，清除行为很难与调节食欲的典型机制相协调，饥饿,和饱腹感。这里,作者提出了一种基于神经科学和人脑成像的模型，以帮助解释在饮食失调患者中看到的有害且通常持续的行为模式，以及为什么很难克服这些模式。这个模型结合了改变饮食的个人动机，恐惧调理，大脑和身体的生物适应，以及恶性循环的发展，驱使个人延续这些行为。这些知识有助于向患者及其家人解释这些疾病，并开发更有效的治疗方法，包括生物干预。
