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Abstract：
T cells play an important role in adaptive immunity. Mature T cells specifically recognize antigens on major histocompatibility complex molecules through T-cell receptors (TCRs). As the TCR repertoire is highly diverse, its analysis is vital in the assessment of T cells. Advances in sequencing technology have provided convenient methods for further investigation of the TCR repertoire. In the present review, the TCR structure and the mechanisms by which TCRs function in tumor recognition are described. In addition, the potential value of the TCR repertoire in tumor diagnosis is reviewed. Furthermore, the role of the TCR repertoire in tumor immunotherapy is introduced, and the relationships between the TCR repertoire and the effects of different tumor immunotherapies are discussed. Based on the reviewed literature, it may be concluded that the TCR repertoire has the potential to serve as a biomarker for tumor prognosis. However, a wider range of cancer types and more diverse subjects require evaluation in future research to establish the TCR repertoire as a biomarker of tumor immunity.
摘要：
T细胞在适应性免疫中起重要作用。成熟T细胞通过T细胞受体(TCR)特异性识别主要组织相容性复合物分子上的抗原。由于TCR曲目高度多样化，它的分析对T细胞的评估至关重要。测序技术的进步为进一步研究TCR库提供了方便的方法。在本次审查中，描述了TCR结构和TCR在肿瘤识别中起作用的机制。此外,综述了TCR库在肿瘤诊断中的潜在价值。此外，介绍了TCR谱在肿瘤免疫治疗中的作用，并讨论了TCR库与不同肿瘤免疫治疗效果之间的关系。根据文献综述，可以得出结论,TCR库具有作为肿瘤预后的生物标志物的潜力。然而,更广泛的癌症类型和更多样化的受试者需要在未来的研究中进行评估，以建立TCR库作为肿瘤免疫的生物标志物。
