PDF(Pubmed)
Abstract：
UNASSIGNED: Postoperative pain (POP) is one of the most common and most important types of pain.
UNASSIGNED: The aim of this study was to compare the effects of pre-emptive oxycodone, diclofenac, and gabapentin on postoperative pain (POP) among patients with tibia fracture surgery.
UNASSIGNED: This double-blind three-group randomised controlled trial was conducted in 2023. Participants were 111 candidates for tibia fracture surgery under general anaesthesia. They were randomly allocated to oxycodone, gabapentin, and diclofenac groups through block randomisation. Baseline arterial oxygen saturation, heart rate, and blood pressure were documented before surgery and POP and sedation status were measured during postoperative recovery and 2, 4, 6, 12, and 24 h after surgery. Postoperative opioid analgesic use was also documented. The data were analysed using the SPSS software (v. 20.0) at a significance level of less than 0.05.
UNASSIGNED: Groups did not significantly differ from each other respecting participants\' baseline age, gender, body mass index, arterial oxygen saturation, heart rate, blood pressure, and surgery duration (P > 0.05). Moreover, there were no significant differences among the groups respecting POP and sedation status at different measurement time points (P > 0.05), except for six hours after surgery at which the POP mean score in the gabapentin group was significantly less than the other two groups (P = 0.001). Among-group differences respecting postoperative use of opioid analgesics and medication side effects were also insignificant (P > 0.05).
UNASSIGNED: Pre-emptive oxycodone, diclofenac, and gabapentin significantly reduce POP among patients with tibia fracture surgery, though gabapentin may produce more significant analgesic effects. All these three medications can be used for pre-emptive analgesia. Of course, the best pre-emptive analgesic agent is determined based on the opinion of the treating physician.
UNASSIGNED: The aim of this study was to compare the effects of pre-emptive oxycodone, diclofenac, and gabapentin on postoperative pain (POP) among patients with tibia fracture surgery.
UNASSIGNED: This double-blind three-group randomised controlled trial was conducted in 2023. Participants were 111 candidates for tibia fracture surgery under general anaesthesia. They were randomly allocated to oxycodone, gabapentin, and diclofenac groups through block randomisation. Baseline arterial oxygen saturation, heart rate, and blood pressure were documented before surgery and POP and sedation status were measured during postoperative recovery and 2, 4, 6, 12, and 24 h after surgery. Postoperative opioid analgesic use was also documented. The data were analysed using the SPSS software (v. 20.0) at a significance level of less than 0.05.
UNASSIGNED: Groups did not significantly differ from each other respecting participants\' baseline age, gender, body mass index, arterial oxygen saturation, heart rate, blood pressure, and surgery duration (P > 0.05). Moreover, there were no significant differences among the groups respecting POP and sedation status at different measurement time points (P > 0.05), except for six hours after surgery at which the POP mean score in the gabapentin group was significantly less than the other two groups (P = 0.001). Among-group differences respecting postoperative use of opioid analgesics and medication side effects were also insignificant (P > 0.05).
UNASSIGNED: Pre-emptive oxycodone, diclofenac, and gabapentin significantly reduce POP among patients with tibia fracture surgery, though gabapentin may produce more significant analgesic effects. All these three medications can be used for pre-emptive analgesia. Of course, the best pre-emptive analgesic agent is determined based on the opinion of the treating physician.
摘要：
■术后疼痛（POP）是最常见，最重要的疼痛类型之一。
■这项研究的目的是比较先发制人的羟考酮的效果，双氯芬酸,和加巴喷丁对胫骨骨折手术患者术后疼痛（POP）的影响。
■这项双盲三组随机对照试验于2023年进行。参与者是111名在全身麻醉下进行胫骨骨折手术的候选人。他们被随机分配给羟考酮，加巴喷丁,和双氯芬酸组通过区组随机化。基线动脉血氧饱和度,心率,术前记录血压，术后恢复期间和术后2、4、6、12和24h测量POP和镇静状态。术后阿片类镇痛药的使用也有记录。使用SPSS软件分析数据(v。20.0）在小于0.05的显著性水平。
■各组在参与者的基线年龄方面没有显着差异，性别,身体质量指数,动脉血氧饱和度,心率,血压,和手术时间(P>0.05)。此外，不同测量时间点的POP和镇静状态组间差异无统计学意义(P>0.05),除了手术后6小时外,加巴喷丁组的POP平均评分明显低于其他两组(P=0.001).术后使用阿片类镇痛药和药物副作用的组间差异也无统计学意义(P>0.05)。
■先发制人的羟考酮，双氯芬酸,和加巴喷丁显著降低了胫骨骨折手术患者的POP，虽然加巴喷丁可能产生更显著的镇痛作用。这三种药物均可用于先发制人镇痛。当然,最佳的先发制人镇痛剂是根据主治医师的意见确定的。
■这项研究的目的是比较先发制人的羟考酮的效果，双氯芬酸,和加巴喷丁对胫骨骨折手术患者术后疼痛（POP）的影响。
■这项双盲三组随机对照试验于2023年进行。参与者是111名在全身麻醉下进行胫骨骨折手术的候选人。他们被随机分配给羟考酮，加巴喷丁,和双氯芬酸组通过区组随机化。基线动脉血氧饱和度,心率,术前记录血压，术后恢复期间和术后2、4、6、12和24h测量POP和镇静状态。术后阿片类镇痛药的使用也有记录。使用SPSS软件分析数据(v。20.0）在小于0.05的显著性水平。
■各组在参与者的基线年龄方面没有显着差异，性别,身体质量指数,动脉血氧饱和度,心率,血压,和手术时间(P>0.05)。此外，不同测量时间点的POP和镇静状态组间差异无统计学意义(P>0.05),除了手术后6小时外,加巴喷丁组的POP平均评分明显低于其他两组(P=0.001).术后使用阿片类镇痛药和药物副作用的组间差异也无统计学意义(P>0.05)。
■先发制人的羟考酮，双氯芬酸,和加巴喷丁显著降低了胫骨骨折手术患者的POP，虽然加巴喷丁可能产生更显著的镇痛作用。这三种药物均可用于先发制人镇痛。当然,最佳的先发制人镇痛剂是根据主治医师的意见确定的。
