PDF(Pubmed)
Abstract：
Recently, a novel method for the growth inhibition of malaria parasites using microwaves was proposed. However, the apparatuses used to demonstrate this method are high-cost and immovable, hindering the progression in this field of research, which is still in its early stages. This paper presents the redesign, construction, and validation of an equivalent system, converting it into a portable and low-cost system, capable of replacing the existing one. The proposed system is mainly composed of an RF generator (MAX2870), an RF amplifier (SKYWORKS 66292-11) and a graphical user interface. Likewise, the RF applicator proposed by the original study was redesigned, resulting in a five-fold improvement in return loss. The obtained results indicate that the proposed system achieves 90% parasite growth inhibition, matching the performance of its counterpart at less than 1% of its cost. These results represent a breakthrough for the creation of smaller, enhanced devices that open new possibilities for an alternative treatment to combat this devastating disease.
摘要：
最近,提出了一种利用微波抑制疟原虫生长的新方法。然而,用于演示这种方法的设备成本高，不可移动，阻碍了这一研究领域的进展，仍处于早期阶段。本文提出了重新设计，建筑,和等效系统的验证，将其转换为便携式且低成本的系统，能够取代现有的。该系统主要由射频发生器(MAX2870)、RF放大器（SKYWORKS66292-11）和图形用户界面。同样，原始研究提出的射频施加器进行了重新设计，导致回波损耗提高了五倍。获得的结果表明，所提出的系统实现了90%的寄生虫生长抑制，以不到其成本的1%匹配其对应方的性能。这些结果代表了创造更小，增强的设备，为对抗这种毁灭性疾病的替代治疗开辟了新的可能性。
