PDF(Pubmed)
Abstract：
Acquired reactive perforating collagenosis (ARPC) is a rare dermatological disorder condition defined by the perforation of altered collagen fibers through the epidermis. The presence of underlying conditions such as diabetes or renal disease is helpful in the ARPC diagnosis. Although skin rashes related to ARPC have been reported, the exact causative factors and mechanisms remain unclear. Here, we present a unique case of ARPC triggered by trauma in a 67-year-old male without concurrent systemic alterations. The diagnosis of ARPC with eosinophilia was made following comprehensive diagnostic testing, including clinical presentation, histological results, and blood tests, ruling out other possible diseases. Intriguingly, the histopathological examination revealed collagen penetration into the epidermis at different tissue sections. In addition, we reviewed existing literature on ARPC, which documented the causation. To help confirm the diagnosis, clinicians have to pay attention to traumatic triggers for ARPC and its rare manifestation with eosinophilia.
摘要：
获得性反应性穿孔胶原病（ARPC）是一种罕见的皮肤病学病症，由改变的胶原纤维通过表皮穿孔定义。糖尿病或肾脏疾病等潜在疾病的存在有助于ARPC诊断。尽管已经报道了与ARPC有关的皮疹，确切的致病因素和机制尚不清楚.这里,我们介绍了一例由创伤引发的ARPC的独特病例,该病例发生在一名67岁男性中,但没有并发全身改变.ARPC伴嗜酸性粒细胞增多的诊断是在综合诊断测试后做出的。包括临床表现，组织学结果,还有血液测试,排除其他可能的疾病。有趣的是，组织病理学检查显示胶原蛋白在不同的组织切片处渗透到表皮中。此外,我们回顾了有关ARPC的现有文献，记录了因果关系。为了帮助确认诊断，临床医生必须注意ARPC的创伤性诱因及其罕见的嗜酸性粒细胞增多表现。
