Abstract：
OBJECTIVE: Robotic transoral mucosectomy of the base of tongue was introduced as a diagnostic procedure in patients treated for head and neck cancer with unknown primary (CUP), increasing the identification rate of the primary tumour. For the treatment of CUP, a considerable percentage of patients require adjuvant (chemo)radiation. The aim of this study was to investigate swallowing outcomes among CUP patients after TORS and adjuvant treatment.
METHODS: A systematic review was carried out on studies investigating the impact of TORS and adjuvant treatment on swallowing-related outcomes among CUP patients In addition, a cross-sectional study was carried out on swallowing problems (measured using the SWAL-QOL questionnaire) among CUP patients in routine care who visited the outpatient clinic 1-5 years after TORS and adjuvant treatment.
RESULTS: The systematic review (6 studies; n = 98) showed that most patients returned to a full oral diet. The cross-sectional study (n = 12) showed that all patients were able to return to a full oral diet, nevertheless, 50% reported swallowing problems in daily life (SWAL-QOL total score ≥14).
CONCLUSIONS: Although after TORS and adjuvant treatment for CUP a full oral diet can be resumed, patients still experience problems with eating and drinking in daily life.
METHODS: A systematic review was carried out on studies investigating the impact of TORS and adjuvant treatment on swallowing-related outcomes among CUP patients In addition, a cross-sectional study was carried out on swallowing problems (measured using the SWAL-QOL questionnaire) among CUP patients in routine care who visited the outpatient clinic 1-5 years after TORS and adjuvant treatment.
RESULTS: The systematic review (6 studies; n = 98) showed that most patients returned to a full oral diet. The cross-sectional study (n = 12) showed that all patients were able to return to a full oral diet, nevertheless, 50% reported swallowing problems in daily life (SWAL-QOL total score ≥14).
CONCLUSIONS: Although after TORS and adjuvant treatment for CUP a full oral diet can be resumed, patients still experience problems with eating and drinking in daily life.
摘要：
目的：机器人经口舌根粘膜切除术被引入作为头颈部原发灶不明（CUP）患者的诊断程序，提高原发肿瘤的识别率。对于CUP的治疗，相当比例的患者需要辅助(化疗)放疗。这项研究的目的是调查TORS和辅助治疗后CUP患者的吞咽结局。
方法：对研究TORS和辅助治疗对CUP患者吞咽相关结局的影响进行了系统评价。我们对接受常规治疗的CUP患者的吞咽问题(使用SWAL-QOL问卷进行测量)进行了横断面研究,这些患者在TORS和辅助治疗后1~5年就诊于门诊.
结果：系统评价（6项研究；n=98）显示，大多数患者恢复了完全的口服饮食。横断面研究（n=12）表明，所有患者都能够恢复完全的口服饮食，然而，50%报告日常生活中存在吞咽问题(SWAL-QOL总分≥14)。
结论：尽管在TORS和CUP辅助治疗后，可以恢复完全口服饮食，患者在日常生活中仍然会遇到饮食问题。
方法：对研究TORS和辅助治疗对CUP患者吞咽相关结局的影响进行了系统评价。我们对接受常规治疗的CUP患者的吞咽问题(使用SWAL-QOL问卷进行测量)进行了横断面研究,这些患者在TORS和辅助治疗后1~5年就诊于门诊.
结果：系统评价（6项研究；n=98）显示，大多数患者恢复了完全的口服饮食。横断面研究（n=12）表明，所有患者都能够恢复完全的口服饮食，然而，50%报告日常生活中存在吞咽问题(SWAL-QOL总分≥14)。
结论：尽管在TORS和CUP辅助治疗后，可以恢复完全口服饮食，患者在日常生活中仍然会遇到饮食问题。
