OBJECTIVE: To investigate the effects of Calorie Restricted Diet (CRD), High Protein Diet (HPD), and High Protein and High Dietary Fiber Diet (HPD+HDF) on body composition, insulin resistance, and oxidative stress in overweight/obese PCOS patients.
METHODS: A total of 90 overweight/obese patients with PCOS were selected to receive an 8- week medical nutrition weight loss intervention at our First Hospital of Peking University, and we randomly divided them into the CRD group (group A), the HPD group (group B), and the HPD+HDF group (group C), with 30 patients in each group. We measured their body composition, HOMA-IR index, and oxidative stress indicators. The t-test, Mann-Whitney U test, analysis of variance (ANOVA), and Kruskal-Wallis H test were used to compare the efficacy of the three methods.
RESULTS: After eight weeks, the body weights of the three groups decreased by 6.32%, 5.70% and 7.24%, respectively, and the Visceral Fat Area (VFA) values decreased by 6.8 cm2, 13.4 cm2 and 23.45 cm2, respectively, especially in group C (p >0.05). The lean body mass (LBM), also known as the Fat-Free Mass (FFM) values of group B and group C after weight loss, were higher than that of group A (p >0.05). After weight loss, the homeostatic model assessment of insulin resistance (HOMA-IR) index and malondialdehyde (MDA) were decreased. Superoxide dismutase (SOD) was increased in all three groups (p >0.05), and the changes in SOD and MDA in group B and group C were more significant (p >0.05). HOMA-IR index positively correlated with body mass index (BMI) (r=0.195; p >0.05); MDA positively correlated with percent of body fat (PBF) (r=0.186; p >0.05) and HOMA-IR index (r=0.422; p >0.01); SOD positively correlated with LMI/FFMI (r=0.195; p >0.05), negatively correlated with HOMA-IR index (r=-0.433; p >0.01).
CONCLUSIONS: All three diets were effective in reducing the body weight of overweight/obese patients with PCOS by more than 5% within 8 weeks and could improve both insulin resistance and oxidative stress damage. Compared with CRD, HPD and HPD+HDF diets could better retain lean body mass and significantly improve oxidative stress damage.
BACKGROUND: ChiCTR2100054961.
目的:为了研究热量限制饮食(CRD)的影响,高蛋白饮食(HPD),和高蛋白和高膳食纤维饮食(HPD+HDF)对身体成分,胰岛素抵抗,超重/肥胖PCOS患者的氧化应激。
方法:选择90例PCOS超重/肥胖患者在北京大学第一医院接受为期8周的医学营养减肥干预。我们将他们随机分为CRD组(A组),HPD组(B组),和HPD+HDF组(C组),每组30名患者。我们测量了他们的身体成分,HOMA-IR指数,和氧化应激指标。t检验,Mann-WhitneyU测试,方差分析(ANOVA),采用Kruskal-WallisH检验比较3种方法的疗效。
结果:八周后,三组的体重下降了6.32%,5.70%和7.24%,分别,内脏脂肪面积(VFA)值分别减少6.8cm2、13.4cm2和23.45cm2,尤其是C组(p>0.05)。瘦体重(LBM),也称为减肥后B组和C组的无脂质量(FFM)值,均高于A组(p>0.05)。减肥后,胰岛素抵抗(HOMA-IR)指数和丙二醛(MDA)的稳态模型评估降低。3组超氧化物歧化酶(SOD)均升高(p>0.05),B组和C组SOD和MDA的变化更为显著(p>0.05)。HOMA-IR指数与体重指数(BMI)呈正相关(r=0.195;p>0.05);MDA与体脂百分比(PBF)呈正相关(r=0.186;p>0.05),HOMA-IR指数呈正相关(r=0.422;p>0.01);SOD与LMI/FFMI呈正相关(r=0.195;p>0.05)。与HOMA-IR指数呈负相关(r=-0.433;p>0.01)。
结论:三种饮食均可在8周内有效降低PCOS超重/肥胖患者体重5%以上,并可改善胰岛素抵抗和氧化应激损伤。与CRD相比,HPD和HPD+HDF饮食可以更好地保持瘦体重,并显着改善氧化应激损伤。
背景:ChiCTR2100054961.