PDF(Pubmed)
Abstract：
Breast cancer is the most common cancer among women worldwide. Breast cancer often metastasizes to the regional lymph nodes, bone, brain, liver, and lungs, whereas gastrointestinal tract metastases are rare. Herein, we present a rare case of rectal metastasis from breast cancer that occurred during palliative chemotherapy. A 69-year-old female with a history of invasive ductal carcinoma, negative for hormonal receptors and positive for human epidermal growth factor receptor 2 (HER2) receptor, underwent various treatments, including neoadjuvant chemotherapy, breast-conserving surgery, and adjuvant therapy. Eight months postoperatively, the patient experienced axillary lymph node recurrence, requiring palliative chemotherapy. Despite ongoing treatment, metastatic lesions were confirmed in the lungs and pleura. During palliative chemotherapy, the patient developed anal pain, and subsequent examination revealed an infiltrating rectal lesion. Despite histological confirmation of metastatic breast carcinoma and tubular adenoma, a multidisciplinary decision was made regarding palliative chemotherapy over surgical intervention. Eribulin was administered, but due to the patient\'s inability to tolerate the treatment, she passed away 3 months after rectal lesion diagnosis. Although breast cancer metastasis to the rectum is rare, clinicians should consider the possibility of rectal involvement and perform a digital rectal examination if anal symptoms are present.
摘要：
乳腺癌是全世界女性中最常见的癌症。乳腺癌经常转移到局部淋巴结，骨头,大脑,肝脏,和肺，而胃肠道转移是罕见的。在这里，我们报道了一例在姑息性化疗期间发生的罕见乳腺癌直肠转移病例.一名69岁女性，有浸润性导管癌病史，激素受体阴性，人类表皮生长因子受体2（HER2）受体阳性，接受了各种治疗，包括新辅助化疗,保乳手术,和辅助治疗。术后八个月,患者腋窝淋巴结复发，需要姑息化疗.尽管正在进行治疗，在肺和胸膜中证实了转移性病变。在姑息化疗期间，病人出现肛门疼痛,随后的检查发现有浸润性直肠病变。尽管组织学证实了转移性乳腺癌和管状腺瘤，关于姑息性化疗优于手术干预的多学科决策.服用了Eribulin，但由于患者无法耐受治疗，她在直肠病变诊断后3个月去世。虽然乳腺癌转移到直肠是罕见的，临床医生应考虑直肠受累的可能性，如果有肛门症状，应进行直肠指检。
