PDF(Pubmed)
Abstract：
OBJECTIVE: This study investigates the association of Body Mass Index (BMI) and age of epilepsy onset, in patients with epilepsy associated with temporal encephaloceles (TEs).
METHODS: A comprehensive PubMed literature review was conducted using the keywords \"temporal encephaloceles\" and \"epilepsy\" for identifying articles for the analysis. Inclusion criteria encompassed all evidence levels reporting patients with TE-related epilepsy and documented BMI. Logistic regression analyses were performed to examine the effect of BMI on predicting epilepsy onset after the 25th year of age. Spearman\'s correlation assessed the relationship between BMI with epilepsy onset. Finally, the association between BMI and postsurgical outcomes, distinguishing between more favourable outcomes (Engel Class I and II) and less favourable outcomes (Engell Class III and IV) was explored.
RESULTS: Of the initially identified 88 articles, nine were included in the analysis, involving 127 patients with TE-related epilepsy and reported BMI. The mean age of epilepsy onset was 24.9 years (SD = 14.8 years), with a mean BMI of 28.0 kg/m2 (SD = 7.4 kg/m2). A significant positive correlation was observed between BMI and age of epilepsy onset (rho = 0.448, p < 0.001). Female patients had higher BMI compared to male patients (30.1 kg/m2, SD = 8.7 kg/m2 and 26.5 kg/m2, SD = 5.3 kg/m2 respectively, p = 0.008). However, the epilepsy onset did not differ significantly between male and female patients (p = 0.26). The bivariate logistic regression showed that patients with increased BMI were more likely to have an epilepsy onset after the 25th year of age, adjusted for the confounder sex (OR = 1.133, 95%-CI [1.060, 1.211], p < 0.001). Finally, a potential trend indicated a higher average BMI among patients with more favourable postsurgical outcomes than less favourable postsurgical outcomes (27.3 kg/m2, SD = 7.7 kg/m2 and 24.8 kg/m2, SD = 2.2 kg/m2 respectively, p = 0.076).
METHODS: A comprehensive PubMed literature review was conducted using the keywords \"temporal encephaloceles\" and \"epilepsy\" for identifying articles for the analysis. Inclusion criteria encompassed all evidence levels reporting patients with TE-related epilepsy and documented BMI. Logistic regression analyses were performed to examine the effect of BMI on predicting epilepsy onset after the 25th year of age. Spearman\'s correlation assessed the relationship between BMI with epilepsy onset. Finally, the association between BMI and postsurgical outcomes, distinguishing between more favourable outcomes (Engel Class I and II) and less favourable outcomes (Engell Class III and IV) was explored.
RESULTS: Of the initially identified 88 articles, nine were included in the analysis, involving 127 patients with TE-related epilepsy and reported BMI. The mean age of epilepsy onset was 24.9 years (SD = 14.8 years), with a mean BMI of 28.0 kg/m2 (SD = 7.4 kg/m2). A significant positive correlation was observed between BMI and age of epilepsy onset (rho = 0.448, p < 0.001). Female patients had higher BMI compared to male patients (30.1 kg/m2, SD = 8.7 kg/m2 and 26.5 kg/m2, SD = 5.3 kg/m2 respectively, p = 0.008). However, the epilepsy onset did not differ significantly between male and female patients (p = 0.26). The bivariate logistic regression showed that patients with increased BMI were more likely to have an epilepsy onset after the 25th year of age, adjusted for the confounder sex (OR = 1.133, 95%-CI [1.060, 1.211], p < 0.001). Finally, a potential trend indicated a higher average BMI among patients with more favourable postsurgical outcomes than less favourable postsurgical outcomes (27.3 kg/m2, SD = 7.7 kg/m2 and 24.8 kg/m2, SD = 2.2 kg/m2 respectively, p = 0.076).
摘要：
目的：这项研究调查了体重指数（BMI）与癫痫发作年龄的关系，与颞叶脑囊肿（TEs）相关的癫痫患者。
方法：使用关键词“颞叶脑瘤”和“癫痫”进行了全面的PubMed文献综述，以确定用于分析的文章。纳入标准包括报告TE相关癫痫患者和记录BMI的所有证据水平。进行Logistic回归分析，以检查BMI对25岁后癫痫发作的预测作用。Spearman相关性评估BMI与癫痫发作之间的关系。最后,BMI与手术后结局之间的关系，我们探讨了比较有利的结果(EngelI类和II类)和较差的结果(EngellIII类和IV类)之间的区别.
结果：在最初确定的88篇文章中，9个被包括在分析中，涉及127例TE相关癫痫患者，报告BMI。癫痫发作的平均年龄为24.9岁（SD=14.8岁），平均BMI为28.0kg/m2（SD=7.4kg/m2）。BMI与癫痫发病年龄呈显著正相关(rho=0.448,p<0.001)。女性患者的BMI高于男性患者(分别为30.1kg/m2,SD=8.7kg/m2和26.5kg/m2,SD=5.3kg/m2,p=0.008)。然而,男性和女性患者的癫痫发作无显著差异(p=0.26).双变量logistic回归分析显示,BMI升高的患者在25岁以后更容易发生癫痫,根据混杂性别调整(OR=1.133，95%-CI[1.060，1.211]，p<0.001)。最后,一个潜在的趋势表明,术后结局较好的患者的平均BMI高于术后结局较差的患者(分别为27.3kg/m2,SD=7.7kg/m2和24.8kg/m2,SD=2.2kg/m2,p=0.076)。
方法：使用关键词“颞叶脑瘤”和“癫痫”进行了全面的PubMed文献综述，以确定用于分析的文章。纳入标准包括报告TE相关癫痫患者和记录BMI的所有证据水平。进行Logistic回归分析，以检查BMI对25岁后癫痫发作的预测作用。Spearman相关性评估BMI与癫痫发作之间的关系。最后,BMI与手术后结局之间的关系，我们探讨了比较有利的结果(EngelI类和II类)和较差的结果(EngellIII类和IV类)之间的区别.
结果：在最初确定的88篇文章中，9个被包括在分析中，涉及127例TE相关癫痫患者，报告BMI。癫痫发作的平均年龄为24.9岁（SD=14.8岁），平均BMI为28.0kg/m2（SD=7.4kg/m2）。BMI与癫痫发病年龄呈显著正相关(rho=0.448,p<0.001)。女性患者的BMI高于男性患者(分别为30.1kg/m2,SD=8.7kg/m2和26.5kg/m2,SD=5.3kg/m2,p=0.008)。然而,男性和女性患者的癫痫发作无显著差异(p=0.26).双变量logistic回归分析显示,BMI升高的患者在25岁以后更容易发生癫痫,根据混杂性别调整(OR=1.133，95%-CI[1.060，1.211]，p<0.001)。最后,一个潜在的趋势表明,术后结局较好的患者的平均BMI高于术后结局较差的患者(分别为27.3kg/m2,SD=7.7kg/m2和24.8kg/m2,SD=2.2kg/m2,p=0.076)。
