PDF(Pubmed)
Abstract：
Bacterial epigenetics, particularly through DNA methylation, exerts significant influence over various biological processes such as DNA replication, uptake, and gene regulation in bacteria. In this review, we explore recent advances in characterizing bacterial epigenomes, accompanied by emerging strategies that harness bacterial epigenetics to elucidate and engineer diverse bacterial species with precision and effectiveness. Furthermore, we delve into the potential of epigenetic modifications to steer microbial functions and influence community dynamics, offering promising opportunities for understanding and modulating microbiomes. Additionally, we investigate the extensive diversity of DNA methyltransferases and emphasize their potential utility in the context of the human microbiome. In summary, this review highlights the potential of DNA methylation as a powerful toolkit for engineering microbiomes.
摘要：
细菌表观遗传学,特别是通过DNA甲基化，对DNA复制等各种生物过程产生重大影响，摄取，和细菌中的基因调控。在这次审查中,我们探索表征细菌表观基因组的最新进展，伴随着利用细菌表观遗传学的新兴策略，以精确和有效地阐明和设计各种细菌物种。此外，我们深入研究了表观遗传修饰引导微生物功能和影响群落动态的潜力，为理解和调节微生物组提供了有希望的机会。此外,我们调查了DNA甲基转移酶的广泛多样性，并强调了它们在人类微生物组中的潜在效用。总之,这篇综述强调了DNA甲基化作为工程微生物组的强大工具包的潜力。
