PDF(Pubmed)
Abstract：
The global incidence of gout has increased rapidly, likely secondary to the increase in the prevalence of conditions that predispose to gout, such as obesity. Depending on the population studied, the prevalence of gout ranges from less than 1 to 6.8%. Thus, gout can be a significant burden on healthcare systems. The objective of this study is to observe the trends in the incidence, prevalence, and disability-adjusted life years (DALYs) of gout between 1990 and 2019 globally and in the European Union (EU) 15+ nations. We extracted data from the Global Burden of Disease Study database based on the International Classification of Diseases (ICD) versions 10 and 9. Incidence, prevalence, and disability-adjusted life years (DALYs) were extracted for individual EU15+ countries and globally in males and females between 1990 and 2019. Joinpoint regression analysis was used to describe trends. Between 1990 and 2019, gout prevalence, incidence, and DALYs increased in both males (+ 21.42%, + 16.87%, + 21.49%, respectively) and females (+ 21.06%, + 18.75%, + 20.66%, respectively) globally. The United States of America had the highest increase in prevalence (males: + 90.6%; females + 47.1%), incidence (males: + 63.73%; females: + 39.11%) and DALYs (males: + 90.43%; females: + 42.75%). Incidence, prevalence, and DALYs from gout are increasing worldwide and in most of the EU15+ countries for males and females. Studies have reported the association of gout with comorbidities such as metabolic syndrome, diabetes mellitus, and cardiovascular disease. Health policies and resource allocation are required to increase awareness and modify risk factors globally.
摘要：
痛风的全球发病率迅速增加，可能是继发于痛风易患疾病患病率的增加，比如肥胖。根据研究的人口，痛风的患病率从不到1%到6.8%不等。因此，痛风可能是医疗保健系统的重大负担。这项研究的目的是观察发病率的趋势，患病率,和1990年至2019年之间全球和欧盟（EU）15个国家的痛风的残疾调整寿命年（DALYs）。我们从基于国际疾病分类（ICD）版本10和9的全球疾病负担研究数据库中提取数据。发病率,患病率,和残疾调整寿命年(DALYs)提取了1990年至2019年期间各个EU15+国家和全球男性和女性。关节点回归分析用于描述趋势。1990年至2019年，痛风患病率，发病率,和DALYs在两个男性中都增加了(+21.42%，+16.87%,+21.49%,分别)和女性(+21.06%，+18.75%,+20.66%,分别）全球。美利坚合众国的患病率最高（男性：90.6％；女性47.1％），发病率(男性:+63.73%;女性:+39.11%)和DALYs(男性:+90.43%;女性:+42.75%)。发病率,患病率,痛风和DALY在全球范围内以及大多数EU15+国家的男性和女性都在增加。有研究报道痛风与代谢综合征等合并症的关系，糖尿病,和心血管疾病。需要卫生政策和资源分配，以提高全球认识并修改风险因素。
