Abstract：
Regulated cell death (RCD) pathways, such as pyroptosis, apoptosis, and necroptosis, are essential for maintaining the body\'s balance, defending against pathogens, and eliminating abnormal cells that could lead to diseases like cancer. Although these pathways operate through distinct mechanisms, recent genetic and pharmacological studies have shown that they can interact and influence each other. The concept of \"PANoptosis\" has emerged, highlighting the interplay between pyroptosis, apoptosis, and necroptosis, especially during cellular responses to infections. This article provides a concise overview of PANoptosis and its molecular mechanisms, exploring its implications in various diseases. The review focuses on the extensive interactions among different RCD pathways, emphasizing the role of PANoptosis in infections, cytokine storms, inflammatory diseases, and cancer. Understanding PANoptosis is crucial for developing novel treatments for conditions involving infections, sterile inflammations, and cancer.
摘要：
调节细胞死亡（RCD）途径，比如焦亡，凋亡，和坏死，对维持身体的平衡至关重要，抵御病原体，消除可能导致癌症等疾病的异常细胞。虽然这些途径通过不同的机制运作，最近的遗传和药理研究表明，它们可以相互作用和相互影响。已经出现了“PANoptosis”的概念，突出了焦度之间的相互作用，凋亡，和坏死，尤其是在细胞对感染的反应期间。本文简要概述了PANoptosis及其分子机制，探索其在各种疾病中的影响。该综述侧重于不同RCD途径之间的广泛相互作用，强调PANoptosis在感染中的作用，细胞因子风暴，炎症性疾病，和癌症。了解PANoptosis对于开发涉及感染的疾病的新型治疗方法至关重要，无菌炎症，和癌症。
