Abstract：
BACKGROUND: Ozone is often used as an additive therapy for skin conditions like infectious diseases, wound healing, diabetic foot, and pressure ulcers. The viability of the nasal skin has crucial importance in revision rhinoplasty cases. The study investigates the potential benefits of medical ozone therapy in healing the nasal skin in multiple-operated cases.
METHODS: The study retrospectively examined 523 revision rhinoplasty patients operated by the first author from January 2017 to January 2024. Patients consenting to ozone therapy received 3 major autohemotherapy sessions post-surgery. Patients were divided into 2 groups: those with compromised nasal skin (infection, poor vascular supply) and those with normal healing. Age, gender, smoking, diabetes, previous surgeries, grafting materials, and techniques were considered.
RESULTS: Of the 523 patients, 12 (2.3%) experienced major skin complications like infection and necrosis, while 511 (97.7%) had no or minor issues, such as discoloration. In total, 301 patients accepted and received ozone therapy. Of the patients without major complications, 299 (58.3%) received ozone therapy, while 212 (41.7%) did not. Among the 12 with major complications, two (16.7%) received ozone therapy, and the remaining 10 (83.3%) did not. Ozone therapy recipients showed statistically fewer skin problems (p<0.05). Costal cartilage as tip and septal extension graft was linked to skin issues (p<0.05). No major adverse effects from ozone therapy were noted.
CONCLUSIONS: Our findings indicate that ozone therapy may be a safe and potentially effective option for patients undergoing revision rhinoplasty, especially those with compromised nasal skin. It appears to aid in skin healing and regeneration, possibly through enhancing oxygen delivery and modulation of the immune response. Ozone therapy is a promising adjunct treatment for managing skin complications in revision rhinoplasty patients.
METHODS: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
METHODS: The study retrospectively examined 523 revision rhinoplasty patients operated by the first author from January 2017 to January 2024. Patients consenting to ozone therapy received 3 major autohemotherapy sessions post-surgery. Patients were divided into 2 groups: those with compromised nasal skin (infection, poor vascular supply) and those with normal healing. Age, gender, smoking, diabetes, previous surgeries, grafting materials, and techniques were considered.
RESULTS: Of the 523 patients, 12 (2.3%) experienced major skin complications like infection and necrosis, while 511 (97.7%) had no or minor issues, such as discoloration. In total, 301 patients accepted and received ozone therapy. Of the patients without major complications, 299 (58.3%) received ozone therapy, while 212 (41.7%) did not. Among the 12 with major complications, two (16.7%) received ozone therapy, and the remaining 10 (83.3%) did not. Ozone therapy recipients showed statistically fewer skin problems (p<0.05). Costal cartilage as tip and septal extension graft was linked to skin issues (p<0.05). No major adverse effects from ozone therapy were noted.
CONCLUSIONS: Our findings indicate that ozone therapy may be a safe and potentially effective option for patients undergoing revision rhinoplasty, especially those with compromised nasal skin. It appears to aid in skin healing and regeneration, possibly through enhancing oxygen delivery and modulation of the immune response. Ozone therapy is a promising adjunct treatment for managing skin complications in revision rhinoplasty patients.
METHODS: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
摘要：
背景：臭氧通常用作皮肤疾病如传染病的添加剂疗法，伤口愈合，糖尿病足,和压疮。鼻部皮肤的生存能力在翻修隆鼻病例中至关重要。该研究调查了医用臭氧治疗在多次手术病例中治愈鼻部皮肤的潜在益处。
方法：本研究回顾性检查了第一作者于2017年1月至2024年1月手术的523例翻修隆鼻患者。同意臭氧治疗的患者在手术后接受了3次主要的自动血液治疗。患者分为2组：鼻部皮肤受损的患者（感染，血管供应不良）和愈合正常的患者。年龄,性别,吸烟,糖尿病,以前的手术，接枝材料,并考虑了技术。
结果：在523名患者中，12人（2.3%）经历了严重的皮肤并发症，如感染和坏死，而511(97.7%)没有或有小问题，比如变色。总的来说,301例患者接受并接受臭氧治疗。在没有重大并发症的患者中，299人（58.3%）接受臭氧治疗，而212人(41.7%)没有。在有严重并发症的12人中，两人(16.7%)接受臭氧治疗,其余10人(83.3%)没有。臭氧治疗接受者表现出统计学上较少的皮肤问题(p<0.05)。作为尖端和间隔延伸移植物的肋骨软骨与皮肤问题有关(p<0.05)。未发现臭氧治疗的主要不良反应。
结论：我们的研究结果表明，对于进行隆鼻翻修的患者，臭氧治疗可能是一种安全且潜在有效的选择。尤其是鼻部皮肤受损的人.它似乎有助于皮肤愈合和再生，可能通过增强氧气输送和调节免疫反应。臭氧疗法是一种有前途的辅助治疗方法，可用于处理翻修隆鼻患者的皮肤并发症。
方法：本期刊要求作者为每篇文章分配一定程度的证据。对于这些循证医学评级的完整描述，请参阅目录或在线作者说明www。springer.com/00266.
方法：本研究回顾性检查了第一作者于2017年1月至2024年1月手术的523例翻修隆鼻患者。同意臭氧治疗的患者在手术后接受了3次主要的自动血液治疗。患者分为2组：鼻部皮肤受损的患者（感染，血管供应不良）和愈合正常的患者。年龄,性别,吸烟,糖尿病,以前的手术，接枝材料,并考虑了技术。
结果：在523名患者中，12人（2.3%）经历了严重的皮肤并发症，如感染和坏死，而511(97.7%)没有或有小问题，比如变色。总的来说,301例患者接受并接受臭氧治疗。在没有重大并发症的患者中，299人（58.3%）接受臭氧治疗，而212人(41.7%)没有。在有严重并发症的12人中，两人(16.7%)接受臭氧治疗,其余10人(83.3%)没有。臭氧治疗接受者表现出统计学上较少的皮肤问题(p<0.05)。作为尖端和间隔延伸移植物的肋骨软骨与皮肤问题有关(p<0.05)。未发现臭氧治疗的主要不良反应。
结论：我们的研究结果表明，对于进行隆鼻翻修的患者，臭氧治疗可能是一种安全且潜在有效的选择。尤其是鼻部皮肤受损的人.它似乎有助于皮肤愈合和再生，可能通过增强氧气输送和调节免疫反应。臭氧疗法是一种有前途的辅助治疗方法，可用于处理翻修隆鼻患者的皮肤并发症。
方法：本期刊要求作者为每篇文章分配一定程度的证据。对于这些循证医学评级的完整描述，请参阅目录或在线作者说明www。springer.com/00266.
