通过用 mRNA LNP 和蛋白质纳米颗粒疫苗进行异源顺序免疫来增强针对流感的交叉保护。
Mesh : Animals Female Humans Mice Administration, Intranasal Antibodies, Viral / immunology Cross Protection / immunology Hemagglutinin Glycoproteins, Influenza Virus / immunology genetics Immunity, Mucosal / immunology Immunization / methods Influenza Vaccines / immunology administration & dosage Lipids / chemistry Liposomes Mice, Inbred BALB C Nanoparticles / chemistry Nanovaccines / administration & dosage immunology Orthomyxoviridae Infections / prevention & control immunology RNA, Messenger / genetics immunology Vaccination / methods
来 源:
DOI:10.1038/s41467-024-50087-5
PDF(Pubmed)