Abstract：
OBJECTIVE: Evaluate clinical and subclinical arteriosclerotic disease in older patients with hip fracture compared with patients without fracture in order to increase knowledge about the relation between both diseases in older individuals.
METHODS: Age- and sex-matched case-control study of octogenarians with and without recent hip fracture. Vascular risk factors, subclinical vascular diseases (assessed by carotid plaques, carotid intima media thickness and arterial stiffness) as well as cardiovascular diseases were analyzed. Univariate and multivariate logistic models were used to estimate odds ratios (OR) with their 95% confidence intervals (CI) to assess the association of the arteriosclerosis and hip fracture.
RESULTS: We analyzed 95 patients per group with a median age of 82 [79-87] years of whom 77.9% were female. Patients in both groups have elevated rates of vascular disease (25%) without differences between them. Patients with hip fracture had higher subclinical arteriosclerotic alterations with higher percentage of carotid plaques (OR 3.25 [1.06-9.97]) compared with the control group.
CONCLUSIONS: Older patients with hip fracture had significantly higher presence of subclinical alterations but not increase on rate of cardiovascular arteriosclerotic disease compared with those without hip fracture.
METHODS: Age- and sex-matched case-control study of octogenarians with and without recent hip fracture. Vascular risk factors, subclinical vascular diseases (assessed by carotid plaques, carotid intima media thickness and arterial stiffness) as well as cardiovascular diseases were analyzed. Univariate and multivariate logistic models were used to estimate odds ratios (OR) with their 95% confidence intervals (CI) to assess the association of the arteriosclerosis and hip fracture.
RESULTS: We analyzed 95 patients per group with a median age of 82 [79-87] years of whom 77.9% were female. Patients in both groups have elevated rates of vascular disease (25%) without differences between them. Patients with hip fracture had higher subclinical arteriosclerotic alterations with higher percentage of carotid plaques (OR 3.25 [1.06-9.97]) compared with the control group.
CONCLUSIONS: Older patients with hip fracture had significantly higher presence of subclinical alterations but not increase on rate of cardiovascular arteriosclerotic disease compared with those without hip fracture.
摘要：
目的：评估老年髋部骨折患者与无骨折患者的临床和亚临床动脉硬化疾病，以增加对老年患者两种疾病之间关系的认识。
方法：年龄和性别相匹配的病例对照研究，研究对象为80岁以上有或无近期髋部骨折。血管危险因素,亚临床血管疾病(通过颈动脉斑块评估，颈动脉内膜中层厚度和动脉僵硬度）以及心血管疾病进行了分析。使用单变量和多变量逻辑模型来估计比值比（OR）及其95％置信区间（CI），以评估动脉硬化和髋部骨折的相关性。
结果：我们分析了每组95例患者，中位年龄为82[79-87]岁，其中77.9%为女性。两组患者的血管疾病发生率均升高（25％），两者之间没有差异。与对照组相比，髋部骨折患者的亚临床动脉硬化改变较高，颈动脉斑块百分比较高（OR3.25[1.06-9.97]）。
结论：与没有髋部骨折的患者相比，老年髋部骨折患者的亚临床改变明显增多，但心血管动脉硬化性疾病的发生率没有增加。
方法：年龄和性别相匹配的病例对照研究，研究对象为80岁以上有或无近期髋部骨折。血管危险因素,亚临床血管疾病(通过颈动脉斑块评估，颈动脉内膜中层厚度和动脉僵硬度）以及心血管疾病进行了分析。使用单变量和多变量逻辑模型来估计比值比（OR）及其95％置信区间（CI），以评估动脉硬化和髋部骨折的相关性。
结果：我们分析了每组95例患者，中位年龄为82[79-87]岁，其中77.9%为女性。两组患者的血管疾病发生率均升高（25％），两者之间没有差异。与对照组相比，髋部骨折患者的亚临床动脉硬化改变较高，颈动脉斑块百分比较高（OR3.25[1.06-9.97]）。
结论：与没有髋部骨折的患者相比，老年髋部骨折患者的亚临床改变明显增多，但心血管动脉硬化性疾病的发生率没有增加。
