Abstract：
OBJECTIVE: To compare the analgesic and sleep quality effects of dexmedetomidine infusion versus placebo in patients undergoing cardiac surgery with ultra-fast track extubation.
METHODS: The randomized, double-blind clinical trial study.
METHODS: At a single academic center hospital.
METHODS: We included patients aged 25 to 65 scheduled for elective cardiac surgery under general anesthesia with cardiopulmonary bypass from October 2021 to December 2022.
METHODS: After immediate extubation in the operating room, the patients who were allocated at first after providing their consent to either the dexmedetomidine group (Dex) or the placebo group (Placebo) received continuous infusion of dexmedetomidine (0.2 μg/kg/h) or saline for 12 hours postoperatively.
RESULTS: The groups\' demographic and perioperative variables were not statistically significant. Total morphine consumption in milligrams at 12 and 24 hours after administered study drug, total sleep time in hours by BIS value ≤85, and sleep quality with the Richard-Campbell Sleep Questionnaire were compared. The analysis included 22 Dex and 23 Placebo patients. The consumption of morphine was not statistically different between the Dex and Placebo groups at 12 and 24 hours (p = 0.707 and p = 0.502, respectively). The Dex group had significantly longer sleep time (8.7 h [7.8, 9.5]) than the Placebo group (5.8 h [2.9, 8.5]; p = 0.007). The Dex group also exhibited better sleep quality (7.9 [6.7, 8.7] vs 6.6 [5.2, 8.0]; p = 0.038).
CONCLUSIONS: Sedation with low-dose dexmedetomidine infusion for ultra-fast track extubation following cardiac surgery enhances sleep duration and quality.
METHODS: The randomized, double-blind clinical trial study.
METHODS: At a single academic center hospital.
METHODS: We included patients aged 25 to 65 scheduled for elective cardiac surgery under general anesthesia with cardiopulmonary bypass from October 2021 to December 2022.
METHODS: After immediate extubation in the operating room, the patients who were allocated at first after providing their consent to either the dexmedetomidine group (Dex) or the placebo group (Placebo) received continuous infusion of dexmedetomidine (0.2 μg/kg/h) or saline for 12 hours postoperatively.
RESULTS: The groups\' demographic and perioperative variables were not statistically significant. Total morphine consumption in milligrams at 12 and 24 hours after administered study drug, total sleep time in hours by BIS value ≤85, and sleep quality with the Richard-Campbell Sleep Questionnaire were compared. The analysis included 22 Dex and 23 Placebo patients. The consumption of morphine was not statistically different between the Dex and Placebo groups at 12 and 24 hours (p = 0.707 and p = 0.502, respectively). The Dex group had significantly longer sleep time (8.7 h [7.8, 9.5]) than the Placebo group (5.8 h [2.9, 8.5]; p = 0.007). The Dex group also exhibited better sleep quality (7.9 [6.7, 8.7] vs 6.6 [5.2, 8.0]; p = 0.038).
CONCLUSIONS: Sedation with low-dose dexmedetomidine infusion for ultra-fast track extubation following cardiac surgery enhances sleep duration and quality.
摘要：
目的：比较右美托咪定与安慰剂对心脏手术患者超快通道拔管的镇痛效果和睡眠质量的影响。
方法：随机，双盲临床试验研究。
方法：在单一学术中心医院。
方法：我们纳入了2021年10月至2022年12月在体外循环全身麻醉下进行择期心脏手术的25至65岁患者。
方法：在手术室立即拔管后，在同意右美托咪定组(Dex)或安慰剂组(安慰剂)后,首次分配的患者术后接受右美托咪定(0.2μg/kg/h)或生理盐水连续输注12小时.
结果：各组人口统计学和围手术期变量无统计学意义。服用研究药物后12和24小时的总吗啡消耗量（毫克），通过BIS值≤85,以小时为单位的总睡眠时间和使用Richard-Campbell睡眠问卷的睡眠质量进行比较。分析包括22名Dex和23名安慰剂患者。在12小时和24小时,Dex组和安慰剂组之间的吗啡消耗没有统计学差异(分别为p=0.707和p=0.502)。Dex组的睡眠时间（8.7h[7.8,9.5]）明显长于安慰剂组（5.8h[2.9,8.5]；p=0.007）。Dex组也表现出更好的睡眠质量(7.9[6.7,8.7]对6.6[5.2,8.0];p=0.038)。
结论：小剂量右美托咪定输注用于心脏手术后超快通道拔管的镇静可提高睡眠时间和质量。
方法：随机，双盲临床试验研究。
方法：在单一学术中心医院。
方法：我们纳入了2021年10月至2022年12月在体外循环全身麻醉下进行择期心脏手术的25至65岁患者。
方法：在手术室立即拔管后，在同意右美托咪定组(Dex)或安慰剂组(安慰剂)后,首次分配的患者术后接受右美托咪定(0.2μg/kg/h)或生理盐水连续输注12小时.
结果：各组人口统计学和围手术期变量无统计学意义。服用研究药物后12和24小时的总吗啡消耗量（毫克），通过BIS值≤85,以小时为单位的总睡眠时间和使用Richard-Campbell睡眠问卷的睡眠质量进行比较。分析包括22名Dex和23名安慰剂患者。在12小时和24小时,Dex组和安慰剂组之间的吗啡消耗没有统计学差异(分别为p=0.707和p=0.502)。Dex组的睡眠时间（8.7h[7.8,9.5]）明显长于安慰剂组（5.8h[2.9,8.5]；p=0.007）。Dex组也表现出更好的睡眠质量(7.9[6.7,8.7]对6.6[5.2,8.0];p=0.038)。
结论：小剂量右美托咪定输注用于心脏手术后超快通道拔管的镇静可提高睡眠时间和质量。
