OBJECTIVE: The use of intraoperative (Local and Intravenous) tranexamic acid reduces blood loss during femoral telescoping nail application in O.I.
METHODS:
METHODS: A prospective randomized controlled study was carried out on 40 patients during applying femoral telescoping nail divided into Group A: (case TXA); 20 patients receiving intraoperative TXA and Group B: (control); 20 patients not receiving TXA. Blood loss and perioperative Hemoglobin (Hb) and Hematocrit Level (Hct) were assessed.
RESULTS: The study included 29 males and 11 females with mean age 7.98 years. The number of osteotomies in both groups ranged from zero to 3 osteotomies with a median one osteotomy. A significant decrease in blood loss was observed in TXA group (mean 241.5 cc) compared to control group (mean 461.5 cc). Postoperative Hb was significantly lower in control group (mean 12.30 g/dL changed to 10.45 g/dL) compared to TXA group (mean 12.26 g/dL changed to 11.52 g/dL). Also, postoperative Hct was significantly lower in control group (m:ean 37.37 % changed to 32.03%) compared to TXA group (mean 36.53 % changed to 34.66 %).
CONCLUSIONS: The use of TXA during femoral telescoping nail application in OI patients has contributed to a remarkable reduction in overall blood loss. Consideration of adding it to management protocol is advised.
METHODS: II; Randomized Controlled Trial (RCT).
目的:术中(局部和静脉)氨甲环酸的使用减少了O.I.股骨伸缩钉应用过程中的失血量。
方法:方法:对40例股骨伸缩钉应用过程中的患者进行了前瞻性随机对照研究,分为A组:(病例TXA);20例接受TXA和B组。评估失血量和围手术期血红蛋白(Hb)和红细胞压积水平(Hct)。
结果:该研究包括29名男性和11名女性,平均年龄为7.98岁。两组的截骨术数量为0至3个截骨术,中位截骨术为1个。与对照组(平均461.5cc)相比,TXA组(平均241.5cc)的失血量显着减少。与TXA组(平均12.26g/dL变为11.52g/dL)相比,对照组术后Hb显着降低(平均12.30g/dL变为10.45g/dL)。此外,与TXA组相比,对照组术后Hct显着降低(m:ean从37.37%变为32.03%)(平均从36.53%变为34.66%)。
结论:在OI患者的股骨伸缩钉应用中使用TXA有助于显著减少总体失血量。建议考虑将其添加到管理协议中。
方法:II;随机对照试验(RCT)。