Abstract：
BACKGROUND: Osteogenesis imperfecta (O.I) is a rare disease caused by an abnormality in type 1 collagen synthesis leading to repeated fractures after low-energy trauma and progressive long bones deformity. Telescoping nail application and surgical correction of these deformities usually necessitates multiple osteotomies and significant bleeding occur due to weakened capillaries and impaired platelet activity. Tranexamic acid (TXA) has an antifibrinolytic effect which is useful in reducing bleeding and need for blood transfusions following several orthopaedic procedures.
OBJECTIVE: The use of intraoperative (Local and Intravenous) tranexamic acid reduces blood loss during femoral telescoping nail application in O.I.
METHODS:
METHODS: A prospective randomized controlled study was carried out on 40 patients during applying femoral telescoping nail divided into Group A: (case TXA); 20 patients receiving intraoperative TXA and Group B: (control); 20 patients not receiving TXA. Blood loss and perioperative Hemoglobin (Hb) and Hematocrit Level (Hct) were assessed.
RESULTS: The study included 29 males and 11 females with mean age 7.98 years. The number of osteotomies in both groups ranged from zero to 3 osteotomies with a median one osteotomy. A significant decrease in blood loss was observed in TXA group (mean 241.5 cc) compared to control group (mean 461.5 cc). Postoperative Hb was significantly lower in control group (mean 12.30 g/dL changed to 10.45 g/dL) compared to TXA group (mean 12.26 g/dL changed to 11.52 g/dL). Also, postoperative Hct was significantly lower in control group (m:ean 37.37 % changed to 32.03%) compared to TXA group (mean 36.53 % changed to 34.66 %).
CONCLUSIONS: The use of TXA during femoral telescoping nail application in OI patients has contributed to a remarkable reduction in overall blood loss. Consideration of adding it to management protocol is advised.
METHODS: II; Randomized Controlled Trial (RCT).
OBJECTIVE: The use of intraoperative (Local and Intravenous) tranexamic acid reduces blood loss during femoral telescoping nail application in O.I.
METHODS:
METHODS: A prospective randomized controlled study was carried out on 40 patients during applying femoral telescoping nail divided into Group A: (case TXA); 20 patients receiving intraoperative TXA and Group B: (control); 20 patients not receiving TXA. Blood loss and perioperative Hemoglobin (Hb) and Hematocrit Level (Hct) were assessed.
RESULTS: The study included 29 males and 11 females with mean age 7.98 years. The number of osteotomies in both groups ranged from zero to 3 osteotomies with a median one osteotomy. A significant decrease in blood loss was observed in TXA group (mean 241.5 cc) compared to control group (mean 461.5 cc). Postoperative Hb was significantly lower in control group (mean 12.30 g/dL changed to 10.45 g/dL) compared to TXA group (mean 12.26 g/dL changed to 11.52 g/dL). Also, postoperative Hct was significantly lower in control group (m:ean 37.37 % changed to 32.03%) compared to TXA group (mean 36.53 % changed to 34.66 %).
CONCLUSIONS: The use of TXA during femoral telescoping nail application in OI patients has contributed to a remarkable reduction in overall blood loss. Consideration of adding it to management protocol is advised.
METHODS: II; Randomized Controlled Trial (RCT).
摘要：
背景：成骨不全症（O.I）是一种罕见的疾病，由1型胶原蛋白合成异常引起，导致低能量创伤和进行性长骨畸形后反复骨折。这些畸形的望远镜钉应用和手术矫正通常需要多次截骨术，并且由于毛细血管减弱和血小板活性受损而发生大量出血。氨甲环酸（TXA）具有抗纤维蛋白溶解作用，可用于减少出血，并在多种骨科手术后需要输血。
目的：术中（局部和静脉）氨甲环酸的使用减少了O.I.股骨伸缩钉应用过程中的失血量。
方法：方法：对40例股骨伸缩钉应用过程中的患者进行了前瞻性随机对照研究，分为A组：（病例TXA）；20例接受TXA和B组。评估失血量和围手术期血红蛋白（Hb）和红细胞压积水平（Hct）。
结果：该研究包括29名男性和11名女性，平均年龄为7.98岁。两组的截骨术数量为0至3个截骨术，中位截骨术为1个。与对照组（平均461.5cc）相比，TXA组（平均241.5cc）的失血量显着减少。与TXA组（平均12.26g/dL变为11.52g/dL）相比，对照组术后Hb显着降低（平均12.30g/dL变为10.45g/dL）。此外，与TXA组相比，对照组术后Hct显着降低（m：ean从37.37％变为32.03％）（平均从36.53％变为34.66％）。
结论：在OI患者的股骨伸缩钉应用中使用TXA有助于显著减少总体失血量。建议考虑将其添加到管理协议中。
方法：II；随机对照试验（RCT）。
目的：术中（局部和静脉）氨甲环酸的使用减少了O.I.股骨伸缩钉应用过程中的失血量。
方法：方法：对40例股骨伸缩钉应用过程中的患者进行了前瞻性随机对照研究，分为A组：（病例TXA）；20例接受TXA和B组。评估失血量和围手术期血红蛋白（Hb）和红细胞压积水平（Hct）。
结果：该研究包括29名男性和11名女性，平均年龄为7.98岁。两组的截骨术数量为0至3个截骨术，中位截骨术为1个。与对照组（平均461.5cc）相比，TXA组（平均241.5cc）的失血量显着减少。与TXA组（平均12.26g/dL变为11.52g/dL）相比，对照组术后Hb显着降低（平均12.30g/dL变为10.45g/dL）。此外，与TXA组相比，对照组术后Hct显着降低（m：ean从37.37％变为32.03％）（平均从36.53％变为34.66％）。
结论：在OI患者的股骨伸缩钉应用中使用TXA有助于显著减少总体失血量。建议考虑将其添加到管理协议中。
方法：II；随机对照试验（RCT）。
