METHODS: A retrospective review was conducted of all robot-assisted LITT procedures performed at our institution between 2013 and 2023 for octogenarians. Comparison of continuous variables was by Student t tests, and Kaplan-Meier estimates were used to estimate survival outcomes.
RESULTS: A total of 20 of 311 (6%) LITT patients in the search cohort were octogenarians. Mean age was 82.6 years (range, 80.1-88.0 years) with 13 (65%) female patients. Brain tumor lesions most commonly were located on the left side (65%), and, for ablation, all were single trajectories with mean number of 2.3 ablations. No operative complications were seen during hospitalization, with mean length of stay of 1.6 days and most common disposition destination being home (95%). There were no 30- or 90-day readmissions or emergency department presentations. Mean follow-up was 12.4 months without any complications in that time. The most common pathology in our cohort was glioblastoma (55%).
CONCLUSIONS: Robot-assisted LITT is a safe and effective treatment option for brain tumors in octogenarians with a very low morbidity risk. Therefore, further investigation is required to understand how LITT can translate to therapeutic benefit in patients aged over 80 years old with brain tumors.
方法:对2013-2023年间在我们机构为八十岁老人进行的所有机器人辅助LITT程序进行了回顾性审查。连续变量的比较采用学生t检验,和Kaplan-Meier估计用于估计生存结局.
结果:搜索队列中共有20/311(6%)名LITT患者为八十岁。平均年龄为82.6岁(范围,80.1-88.0),有13名(65%)女性。脑肿瘤病变最常见的是位于左侧(65%),和消融,所有均为单轨迹,平均消融次数为2.3次.住院期间未见手术并发症,平均逗留时间为1.6天,最常见的处置目的地是家(95%)。没有30天或90天的再入院或急诊室介绍。平均随访时间为12.4个月,在此期间没有任何并发症。我们队列中最常见的病理是胶质母细胞瘤(GBM,55%)。
结论:机器人辅助LITT是一种安全有效的治疗八十岁老人脑肿瘤的选择,发病率风险非常低。因此,需要进一步的研究来了解LITT如何在80岁以上的脑肿瘤患者中转化为治疗获益.