Abstract：
BACKGROUND: Randomized controlled trials (RCTs) provide information on appropriate management protocols in patients with cerebrovascular diseases. Despite growing evidence of race and ethnicity being independent predictors of outcomes, recent literature has drawn attention to inadequate reporting of these demographic profiles across RCTs. To our knowledge, the adherence to reporting race and/or ethnicity in cerebrovascular RCTs remains undescribed. Our study describes trends in the reporting of race and/or ethnicity across cerebrovascular RCTs.
METHODS: Web of Science was searched to identify the top 100-cited cerebrovascular RCTs. Additional articles were retrieved from guidelines issued by the American Heart Association for the management of ischemic stroke, intracerebral hemorrhage, and aneurysmal subarachnoid hemorrhage. Univariate and multivariate analyses were performed to assess for factors influencing reporting of race/ethnicity.
RESULTS: Sixty-five percent of cerebrovascular RCTs lacked reporting of participant race and/or ethnicity. Multivariate regression revealed that studies from North America had a 14.74- fold higher odds (95% CI: 4.574-47.519) of reporting race/ethnicity. Impact factor of the journal was associated with 1.007-fold odds of reporting race/ethnicity (95% CI: 1.000-1.013). Reporting of race and/or ethnicity did not increase with time, or vary according to the number of participating centers, median number of study participants, source of funding, or category of RCT. Among RCTs that reported race, Blacks and Asians were underrepresented compared to Whites.
CONCLUSIONS: Sixty-five percent of prominent cerebrovascular RCTs lack adequate reporting of participant race/ethnicity. Reasons for inadequate reporting of these variables remain unclear and warrant additional investigation.
METHODS: Web of Science was searched to identify the top 100-cited cerebrovascular RCTs. Additional articles were retrieved from guidelines issued by the American Heart Association for the management of ischemic stroke, intracerebral hemorrhage, and aneurysmal subarachnoid hemorrhage. Univariate and multivariate analyses were performed to assess for factors influencing reporting of race/ethnicity.
RESULTS: Sixty-five percent of cerebrovascular RCTs lacked reporting of participant race and/or ethnicity. Multivariate regression revealed that studies from North America had a 14.74- fold higher odds (95% CI: 4.574-47.519) of reporting race/ethnicity. Impact factor of the journal was associated with 1.007-fold odds of reporting race/ethnicity (95% CI: 1.000-1.013). Reporting of race and/or ethnicity did not increase with time, or vary according to the number of participating centers, median number of study participants, source of funding, or category of RCT. Among RCTs that reported race, Blacks and Asians were underrepresented compared to Whites.
CONCLUSIONS: Sixty-five percent of prominent cerebrovascular RCTs lack adequate reporting of participant race/ethnicity. Reasons for inadequate reporting of these variables remain unclear and warrant additional investigation.
摘要：
背景：随机对照试验（RCT）提供了有关脑血管疾病患者的适当治疗方案的信息。尽管越来越多的证据表明种族和族裔是结果的独立预测因子，最近的文献引起了人们对RCT中这些人口统计学特征报告不足的关注。据我们所知,脑血管RCT中对报告种族和/或种族的依从性仍未描述.我们的研究描述了脑血管RCT中种族和/或种族的报告趋势。
方法：搜索WebofScience以确定排名前100位的脑血管RCT。其他文章来自美国心脏协会（AHA）发布的缺血性卒中管理指南，脑出血（ICH）和动脉瘤性蛛网膜下腔出血（aSAH）。进行单变量和多变量分析以评估影响种族/民族报告的因素。
结果：65%的脑血管随机对照试验缺乏参与者种族和/或民族的报告。多因素回归显示，来自北美的研究报告种族/民族的几率高14.74倍（95％CI：4.574-47.519]。该期刊的影响因子与报告种族/民族的1.007倍几率相关[95%CI:1.000-1.013]。种族和/或种族的报告并没有随着时间的推移而增加，或根据参与中心的数量而变化，研究参与者的中位数，资金来源或RCT类别。在报告种族的RCT中，与白人相比，黑人和亚洲人的代表性不足。
结论：65%的突出脑血管RCT缺乏足够的参与者种族/民族报告。这些变量报告不足的原因尚不清楚，需要进一步调查。
方法：搜索WebofScience以确定排名前100位的脑血管RCT。其他文章来自美国心脏协会（AHA）发布的缺血性卒中管理指南，脑出血（ICH）和动脉瘤性蛛网膜下腔出血（aSAH）。进行单变量和多变量分析以评估影响种族/民族报告的因素。
结果：65%的脑血管随机对照试验缺乏参与者种族和/或民族的报告。多因素回归显示，来自北美的研究报告种族/民族的几率高14.74倍（95％CI：4.574-47.519]。该期刊的影响因子与报告种族/民族的1.007倍几率相关[95%CI:1.000-1.013]。种族和/或种族的报告并没有随着时间的推移而增加，或根据参与中心的数量而变化，研究参与者的中位数，资金来源或RCT类别。在报告种族的RCT中，与白人相比，黑人和亚洲人的代表性不足。
结论：65%的突出脑血管RCT缺乏足够的参与者种族/民族报告。这些变量报告不足的原因尚不清楚，需要进一步调查。
