Abstract:
The use of radiation therapy (RT) for pancreatic cancer continues to be controversial, despite recent technical advances. Improvements in systemic control have created an evolving role for RT and the need for improved local tumor control, but currently, no standardized approach exists. Advances in stereotactic body RT, motion management, real-time image guidance, and adaptive therapy have renewed hopes of improved outcomes in this devastating disease with one of the lowest survival rates. This case-based guide provides a practical framework for delivering stereotactic body RT for locally advanced pancreatic cancer. In conjunction with multidisciplinary care, an intradisciplinary approach should guide treatment of the high-risk cases outlined within these guidelines for prospective peer review and treatment safety discussions.
摘要:
尽管最近的技术进步,胰腺癌的放射治疗(RT)的使用仍然存在争议。全身性控制的改进已经为RT创造了不断发展的作用,并且需要改进的局部肿瘤控制,但是目前不存在标准化方法。立体定向身体放射治疗(SBRT)的进展,运动管理,实时图像指导和自适应治疗使人们重新获得了改善这种破坏性疾病预后的希望,这是生存率最低的疾病之一。本基于病例的指南为提供针对局部晚期胰腺癌的SBRT提供了一个实用的框架。结合多学科护理,在前瞻性同行评审和治疗安全性讨论中,本指南中概述的高危病例应采用学科内方法指导治疗.