Abstract：
This report evaluates the effects of chlordiazepoxide, a benzodiazepine commonly prescribed to manage anxiety-related disorders in adolescent/pediatric populations, on elevated plus maze (EPM) performance in juvenile mice. This approach was taken because chlordiazepoxide produces anxiolytic-like effects in multiple models in adult rodents, however, less is known about the behavioral effects of this benzodiazepine in juveniles. Thus, we administered a single intraperitoneal injection of chlordiazepoxide (0, 5, or 10 mg/kg) to postnatal day 35 male C57BL/6 mice. Thirty minutes later, mice were allowed to explore the EPM for 5-min. We found that chlordiazepoxide-treated mice (5 and 10 mg/kg) spent more time exploring the open arms of the EPM. No differences in velocity (cm/s) or distance traveled (cm) were observed between the groups. These results indicate that chlordiazepoxide induces anxiolytic-related behavior in adolescent male mice.
摘要：
本报告评估了氯二氮卓的影响，一种通常用于治疗青少年/儿科人群焦虑相关疾病的苯二氮卓类药物，幼年小鼠的高架迷宫（EPM）表现。采取这种方法是因为氯二氮卓在成年啮齿动物的多种模型中产生抗焦虑作用，然而,对这种苯二氮卓类药物对青少年的行为影响知之甚少。因此，我们对出生后第35天的雄性C57BL/6小鼠单次腹膜内注射氯二氮卓(0,5或10mg/kg).三十分钟后,允许小鼠探索EPM5分钟。我们发现氯二氮卓治疗的小鼠（5和10mg/kg）花费更多的时间探索EPM的开放臂。两组之间没有观察到速度（cm/s）或行进距离（cm）的差异。这些结果表明，氯二氮卓可诱导青春期雄性小鼠的抗焦虑相关行为。
