PDF(Pubmed)
Abstract：
BACKGROUND: Preterm infants are highly susceptible to infections, which significantly contribute to morbidity and mortality. This systematic review and meta-analysis investigated the effectiveness of topical emollient oil application in preventing infections among preterm infants.
METHODS: A comprehensive search was conducted across multiple electronic databases (PubMed, Cochrane, Scopus, Clinical trials, Epistemonikos, HINARI and Global Index Medicus) and other sources. A total of 2185 articles were identified and screened for eligibility. The quality of included studies was assessed using the Cochrane Risk of Bias Tool for randomised controlled trials. Data analysis was performed using StataCrop MP V.17 software. Heterogeneity among the studies was evaluated using the I2 and Cochrane Q test statistics. Sensitivity and subgroup analyses were conducted. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist guided the presentation of the results.
RESULTS: Of 2185 retrieved articles from initial searches, 11 met eligibility criteria and were included in the final analysis. A random effects meta-analysis revealed that infants who received massages with emollient oils had a 21% reduced risk of infection (risk ratio=0.79, 95% CI 0.64 to 0.97, I2=0.00%). Subgroup analyses indicated that preterm babies who received topical emollient oil massages with coconut oil, administered twice a day for more than 2 weeks, had a lower likelihood of acquiring an infection compared with their non-massaged counterparts.
CONCLUSIONS: It is quite evident from this analysis that topical emollient oil application in preterm neonates is most likely effective in preventing infection. However, further studies, particularly from the African continent, are warranted to support universal recommendations.
METHODS: A comprehensive search was conducted across multiple electronic databases (PubMed, Cochrane, Scopus, Clinical trials, Epistemonikos, HINARI and Global Index Medicus) and other sources. A total of 2185 articles were identified and screened for eligibility. The quality of included studies was assessed using the Cochrane Risk of Bias Tool for randomised controlled trials. Data analysis was performed using StataCrop MP V.17 software. Heterogeneity among the studies was evaluated using the I2 and Cochrane Q test statistics. Sensitivity and subgroup analyses were conducted. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist guided the presentation of the results.
RESULTS: Of 2185 retrieved articles from initial searches, 11 met eligibility criteria and were included in the final analysis. A random effects meta-analysis revealed that infants who received massages with emollient oils had a 21% reduced risk of infection (risk ratio=0.79, 95% CI 0.64 to 0.97, I2=0.00%). Subgroup analyses indicated that preterm babies who received topical emollient oil massages with coconut oil, administered twice a day for more than 2 weeks, had a lower likelihood of acquiring an infection compared with their non-massaged counterparts.
CONCLUSIONS: It is quite evident from this analysis that topical emollient oil application in preterm neonates is most likely effective in preventing infection. However, further studies, particularly from the African continent, are warranted to support universal recommendations.
摘要：
背景：早产儿极易感染，这显著增加了发病率和死亡率。这项系统评价和荟萃分析调查了局部使用润肤油预防早产儿感染的有效性。
方法：在多个电子数据库（PubMed，科克伦,Scopus,临床试验,认识论，HINARI和全球指数Medicus)和其他来源。总共确定了2185篇文章，并对其进行了资格筛选。纳入研究的质量使用Cochrane偏差风险工具进行随机对照试验评估。使用StataCropMPV.17软件进行数据分析。使用I2和CochraneQ检验统计量评估研究之间的异质性。进行敏感性和亚组分析。系统审查和荟萃分析的首选报告项目清单指导了结果的呈现。
结果：在从初始搜索中检索到的2185篇文章中，11人符合资格标准，并被纳入最终分析。随机效应荟萃分析显示，接受润肤油按摩的婴儿感染风险降低了21％（风险比=0.79，95％CI0.64至0.97，I2=0.00％）。亚组分析表明，接受椰子油局部润肤油按摩的早产儿，每天给药两次，持续超过2周，与未按摩的同行相比，感染的可能性较低。
结论：从这项分析中可以很明显地看出，早产儿局部使用润肤油可能最有效地预防感染。然而,进一步研究,特别是来自非洲大陆的，有必要支持普遍的建议。
方法：在多个电子数据库（PubMed，科克伦,Scopus,临床试验,认识论，HINARI和全球指数Medicus)和其他来源。总共确定了2185篇文章，并对其进行了资格筛选。纳入研究的质量使用Cochrane偏差风险工具进行随机对照试验评估。使用StataCropMPV.17软件进行数据分析。使用I2和CochraneQ检验统计量评估研究之间的异质性。进行敏感性和亚组分析。系统审查和荟萃分析的首选报告项目清单指导了结果的呈现。
结果：在从初始搜索中检索到的2185篇文章中，11人符合资格标准，并被纳入最终分析。随机效应荟萃分析显示，接受润肤油按摩的婴儿感染风险降低了21％（风险比=0.79，95％CI0.64至0.97，I2=0.00％）。亚组分析表明，接受椰子油局部润肤油按摩的早产儿，每天给药两次，持续超过2周，与未按摩的同行相比，感染的可能性较低。
结论：从这项分析中可以很明显地看出，早产儿局部使用润肤油可能最有效地预防感染。然而,进一步研究,特别是来自非洲大陆的，有必要支持普遍的建议。
