Abstract：
Acinetobacter baumannii with the capability to \"escape\" almost all currently available antibacterials is eroding the safety of basic medical interventions and is an increasing cause of mortality globally, prompting a substantial requirement for new classes of antibacterial agents. Indoles participate in the regulation of persistent bacterial formation, biofilm formation, plasmid stability, and drug resistance. In particular, indole hybrids demonstrated promising antibacterial activity against both drug-sensitive and drug-resistant A. baumannii pathogens, representing a fertile source for the discovery of novel therapeutic agents for clinical deployment in controlling A. baumannii infections. This mini-review outlines the current innovations of indole hybrids with antibacterial activity against A. baumannii pathogens, covering articles published from 2020 to the present, to open new avenues for exploring novel anti-A. baumannii candidates.
摘要：
鲍曼不动杆菌具有“逃脱”的能力，目前几乎所有可用的抗菌药物正在侵蚀基本医疗干预措施的安全性，并且是全球死亡率上升的原因，促使对新型抗菌剂的大量需求。吲哚参与持久性细菌形成的调节，生物膜的形成，质粒稳定性，和抗药性。特别是,吲哚杂种对药物敏感性和耐药性鲍曼不动杆菌病原体均具有良好的抗菌活性，代表发现用于控制鲍曼不动杆菌感染的临床部署的新型治疗剂的肥沃来源。这篇小型综述概述了吲哚杂种对鲍曼不动杆菌病原体具有抗菌活性的当前创新，涵盖2020年至今发表的文章，为探索反A小说开辟新的途径鲍曼尼候选人.
