PDF(Pubmed)
Abstract：
BACKGROUND: Oral Submucous Fibrosis, OSF is an inflammatory mucosal disorder prevalent in areca nut chewing belts of the world. Although various treatments are available for its management, none provide complete resolution.Curcumin, an indigenous product, improves burning sensation, mouth opening along with other clinical signs of OSF and is potentially viable therapeutic option for its management.
OBJECTIVE: To assess the available evidence for employing curcumin in improving symptoms in patients with OSF.
METHODS: Systematic search was carried out in e-databases from January 2010 until July 2023 to identify relevant clinical trials comparing curcumin to active and/or nonactive controls (placebo) for the management of OSF.
RESULTS: A total of 20 studies were used for qualitative analysis out of which 11 studies were considered for quantitative synthesis.Curcumin was found to be highly effective in alleviating pain/burning sensation, improving mouth opening (MO), cheek flexibility, tongue protrusion and induces positive histological changes in patients with OSF.The standardized mean difference in mouth opening between both the Curcumin and Multivitamin group showed a statistically significant difference favouring the Curcumin group (SMD, 0.37, 95% CI = 0.18-0.56, p - 0.0001, I2- 0%).
CONCLUSIONS: Statistically curcumin was noted to be as effective as Aloe vera, lycopene and steroids in relieving symptoms of OSF in stages 1 and 2 and improving MO. It is seen to improve histopathological picture of lesions thereby suggesting its active role in preventing malignant transformation. Its found to be more effective than multivitamins in improving mouth opening of patients in OSF.
OBJECTIVE: To assess the available evidence for employing curcumin in improving symptoms in patients with OSF.
METHODS: Systematic search was carried out in e-databases from January 2010 until July 2023 to identify relevant clinical trials comparing curcumin to active and/or nonactive controls (placebo) for the management of OSF.
RESULTS: A total of 20 studies were used for qualitative analysis out of which 11 studies were considered for quantitative synthesis.Curcumin was found to be highly effective in alleviating pain/burning sensation, improving mouth opening (MO), cheek flexibility, tongue protrusion and induces positive histological changes in patients with OSF.The standardized mean difference in mouth opening between both the Curcumin and Multivitamin group showed a statistically significant difference favouring the Curcumin group (SMD, 0.37, 95% CI = 0.18-0.56, p - 0.0001, I2- 0%).
CONCLUSIONS: Statistically curcumin was noted to be as effective as Aloe vera, lycopene and steroids in relieving symptoms of OSF in stages 1 and 2 and improving MO. It is seen to improve histopathological picture of lesions thereby suggesting its active role in preventing malignant transformation. Its found to be more effective than multivitamins in improving mouth opening of patients in OSF.
摘要：
背景：口腔粘膜下纤维化，OSF是世界槟榔咀嚼带中普遍存在的炎性粘膜病症。尽管有各种治疗方法可用于其管理，没有提供完整的解决方案。姜黄素,一种本土产品，改善灼烧感，张口以及OSF的其他临床症状，是治疗OSF的潜在可行治疗选择。
目的：评估使用姜黄素改善OSF患者症状的现有证据。
方法：从2010年1月至2023年7月在电子数据库中进行了系统搜索，以确定将姜黄素与活性和/或非活性对照（安慰剂）进行比较以管理OSF的相关临床试验。
结果：共20项研究用于定性分析，其中11项研究用于定量合成。发现姜黄素在缓解疼痛/烧灼感方面非常有效，改善张口(MO)，脸颊的灵活性，OSF患者的舌头突出并诱导阳性组织学变化。姜黄素组和多种维生素组之间张口的标准化平均差异显示出有利于姜黄素组的统计学显着差异（SMD，0.37，95%CI=0.18-0.56，p-0.0001，I2-0%）。
结论：统计表明姜黄素与芦荟一样有效，番茄红素和类固醇在缓解1和2期OSF症状和改善MO中的作用。可以改善病变的组织病理学特征，从而表明其在预防恶性转化中的积极作用。发现它在改善OSF患者的张口方面比多种维生素更有效。
目的：评估使用姜黄素改善OSF患者症状的现有证据。
方法：从2010年1月至2023年7月在电子数据库中进行了系统搜索，以确定将姜黄素与活性和/或非活性对照（安慰剂）进行比较以管理OSF的相关临床试验。
结果：共20项研究用于定性分析，其中11项研究用于定量合成。发现姜黄素在缓解疼痛/烧灼感方面非常有效，改善张口(MO)，脸颊的灵活性，OSF患者的舌头突出并诱导阳性组织学变化。姜黄素组和多种维生素组之间张口的标准化平均差异显示出有利于姜黄素组的统计学显着差异（SMD，0.37，95%CI=0.18-0.56，p-0.0001，I2-0%）。
结论：统计表明姜黄素与芦荟一样有效，番茄红素和类固醇在缓解1和2期OSF症状和改善MO中的作用。可以改善病变的组织病理学特征，从而表明其在预防恶性转化中的积极作用。发现它在改善OSF患者的张口方面比多种维生素更有效。
