Abstract：
The male reproductive system provides a distinctive shield to the immune system, safeguarding germ cells (GCs) from autoimmune harm. The testis in mammals creates a unique immunological setting due to its exceptional immune privilege and potent local innate immunity. which can result from a number of different circumstances, including disorders of the pituitary gland, GC aplasia, and immunological elements. Apoptosis, or programmed cell death (PCD), is essential for mammalian spermatogenesis to maintain and ensure an appropriate number of GCs that correspond with the supporting capability of the Sertoli cells. Apoptosis is substantial in controlling the number of GCs in the testis throughout spermatogenesis, and any dysregulation of this process has been linked to male infertility. There is a number of evidence about the potential of PCD in designing novel therapeutic approaches in the treatment of infertility. A detailed understanding of PCD and the processes that underlie immunological infertility can contribute to the progress in designing strategies to prevent and treat male infertility. This review will provide a summary of the role of immune cell death in male reproduction and infertility and describe the therapeutic strategies and agents for treatment based on immune cell death.
摘要：
男性生殖系统为免疫系统提供了独特的屏障，保护生殖细胞（GC）免受自身免疫伤害。由于其特殊的免疫特权和有效的局部先天免疫，哺乳动物的睾丸产生了独特的免疫学环境。这可能是由许多不同的情况导致的，包括垂体疾病，GC再生障碍,和免疫学元素。细胞凋亡,或程序性细胞死亡(PCD)，是哺乳动物精子发生所必需的，以维持和确保与支持支持细胞的能力相对应的适当数量的GC。凋亡在整个精子发生过程中控制睾丸中的GC数量方面具有重要意义，这个过程的任何失调都与男性不育有关。有许多证据表明PCD在设计治疗不孕症的新治疗方法中的潜力。详细了解PCD和导致免疫性不育症的过程可以有助于设计预防和治疗男性不育症的策略。这篇综述将概述免疫细胞死亡在男性生殖和不育中的作用，并描述基于免疫细胞死亡的治疗策略和治疗药物。
