Abstract：
The recent study delves into the role of both liraglutide and/or resveratrol on the nephropathic affection in rats treated with cyclosporine A (CsA). Rats were intoxicated with CsA (25 mg/kg) orally for 21 days and were supplemented with liraglutide (30 μg/kg) s/c daily and 20 mg/kg of resveratrol (20 mg/kg) orally. At the end of the experiment, serum samples and renal tissues were collected to determine renal damage markers, apoptotic markers, proinflammatory markers, and antioxidant status markers. Kidney function tests and antioxidant activity notably improved in the treated rats (CsA + Lir/CsA + Res/CsA + Lir + Res). Moreover, both Lir and/or Res enhanced Bcl-2 levels while down-regulating the Bax levels in rats treated with CsA. Interestingly, the immune-staining for tumor necrosis factor (TNF-α) was tested negative and mild positive in renal tissue of rats given Lir and/or Res while being treated with Cs A which indicated their anti-inflammatory effect that reduced the renal damage. The findings of this investigation revealed the ameliorative anti-inflammatory in addition to the antioxidant role of both liraglutide and resveratrol against the kidney damage caused due to CsA administration.
摘要：
最近的研究探讨了利拉鲁肽和/或白藜芦醇对环孢素A（CsA）治疗大鼠肾病的作用。大鼠口服CsA（25mg/kg）中毒21天，每天补充利拉鲁肽（30μg/kg）s/c和20mg/kg白藜芦醇（20mg/kg）。实验结束时,收集血清样本和肾组织以确定肾损伤标志物，凋亡标志物，促炎标志物，和抗氧化剂状态标记。在治疗的大鼠(CsA+Lir/CsA+Res/CsA+Lir+Res)中,肾功能测试和抗氧化活性显著改善。此外，在用CsA处理的大鼠中,Lir和/或Res均增强Bcl-2水平,同时下调Bax水平。有趣的是,在接受Lir和/或Res治疗的大鼠的肾组织中，肿瘤坏死因子（TNF-α）的免疫染色测试为阴性和轻度阳性，同时接受CsA治疗，这表明它们的抗炎作用减轻了肾损伤。这项研究的发现表明，除了利拉鲁肽和白藜芦醇对CsA给药引起的肾脏损害的抗氧化作用外，还具有改善的抗炎作用。
