PDF(Pubmed)
Abstract：
The Pelargonium genus encompasses around 280 species, most of which are used for medicinal purposes. While P. graveolens, P. odoratissimum, and P. zonale are known to exhibit antimicrobial activity, there is an evident absence of studies evaluating all three species to understand their chemical differences and biological effects. Through the analysis of the hydroalcoholic extracts of P. graveolens, P. odoratissimum, and P. zonale, using HPLC-DAD-MS/MS, quercetin and kaempferol derivatives were identified in these three species. Conversely, gallotannins and anthocyanins were uniquely detected in P. zonale. P. graveolens stood out due to the various types of myricetin derivatives that were not detected in P. odoratissimum and P. zonale extracts. Evaluation of their biological activities revealed that P. zonale displayed superior antibacterial and antibiofilm activities in comparison to the other two species. The antibacterial efficacy of P. zonale was observed towards the clinically relevant strains of Staphylococcus aureus ATCC 25923, Methicillin-resistant Staphylococcus aureus (MRSA) 333, Enterococcus faecalis ATCC 29212, and the Vancomycin-resistant E. faecalis INSPI 032. Fractionation analysis of P. zonale suggested that the antibacterial activity attributed to this plant is due to the presence of quercetin derivatives and kaempferol and its derivatives, alongside their synergistic interaction with gallotannins and anthocyanins. Lastly, the three Pelargonium species exhibited notable antioxidant activity, which may be attributed to their high content of total phenolic compounds.
摘要：
天花属涵盖约280种，其中大部分用于医疗目的。而P.graveolens,P.ododatissimum，和P.zonale已知表现出抗菌活性，显然没有研究评估这三个物种以了解它们的化学差异和生物学效应。通过对甘草的水醇提取物的分析，P.ododatissimum，还有P.zonale,采用HPLC-DAD-MS/MS,在这三个物种中鉴定出槲皮素和山奈酚衍生物。相反，胆单宁和花色苷是在P.zonale中唯一检测到的。P.graveolens脱颖而出，由于各种类型的杨梅素衍生物，未检测到在P.ododatissimum和P.zonale提取物。对其生物活性的评估表明，与其他两个物种相比，P.zonale显示出优异的抗菌和抗生物膜活性。观察到P.zonale对金黄色葡萄球菌ATCC25923、耐甲氧西林金黄色葡萄球菌(MRSA)333、粪肠球菌ATCC29212和耐万古霉素粪肠球菌INSPI032的临床相关菌株的抗菌功效。P.zonale的分级分析表明，归因于该植物的抗菌活性是由于槲皮素衍生物和山奈酚及其衍生物的存在，以及它们与没食子酸和花色苷的协同相互作用。最后,这三种天竺葵物种表现出显著的抗氧化活性，这可能归因于它们的总酚类化合物含量高。
