Abstract：
We assess the associations between personality traits and co-occurrence of depressive symptoms and high BMI from adolescence to early adulthood. We employed a nationally representative cohort in China from 2010 to 2020 year. We included adolescents aged 10-19 years without depressive symptoms and unhealthy weight status (obesity, overweight, or thinness) at baseline and excluded those without any measurement of depressive symptoms or BMI at follow-ups. We assessed baseline personality traits in 7 dimensions of conscientiousness, openness, neuroticism, agreeableness, extraversion, self-esteem, and responsibility. We also assessed the combined effects of these 7 dimensions of personality traits by generating individual-level personality trait risk scores based on the weighted sum of all these 7 dimensions of personality traits. We measured the co-occurrence of depressive symptoms and high BMI using both a single measurement of depressive symptoms and BMI at the last follow-up and repeated measurements of them over 10 years. We used the multinomial logistic regression models to examine the exposure-outcome associations. At baseline, we included 1778 individuals (mean age: 14.4 year; female: 853 (48.0%)). At follow-ups, we observed increased risk of co-occurrence of depressive symptoms and high BMI per 1-SD increase in neuroticism score (1.95-2.38 odds ratio) or 1-SD decrease in self-esteem and conscientiousness (0.63-0.80 odds ratio; all P values < 0.05); we observed no evidence of associations between openness, agreeableness, extraversion, or responsibility and the risk of co-occurrence of depressive symptoms and high BMI (all P values > 0.05). For the combined effects of the 7 dimensions of personality traits, we found an elevated risk of co-occurrence of depressive symptoms and high BMI per 1-SD increase in the personality trait risk scores (OR (95% CI), single measurement at the last follow-up: 2.01, 1.66 to 2.43; trajectory classification using the repeated measurements 2.30, 1.55 to 3.42; average level using the repeated measurements: 2.27, 1.93 to 2.67). In this national cohort in China, personality traits were found to be associated with the co-occurrence of depressive symptoms and high BMI from adolescence to early adulthood. These findings highlight the importance of stratifying individuals based on their personality traits and providing targeted interventions for those at risk of comorbid depression and obesity.
摘要：
我们评估了从青春期到成年早期的人格特质与抑郁症状和高BMI之间的关联。从2010年到2020年，我们在中国采用了具有全国代表性的队列。我们纳入了10-19岁没有抑郁症状和不健康体重状态的青少年(肥胖，超重,或薄度）在基线，并排除那些在随访时没有任何抑郁症状或BMI测量的人。我们在认真的7个维度上评估了基线人格特质，开放性,神经质,令人愉快，外向,自尊,和责任。我们还通过根据所有这7个人格特质维度的加权和生成个体层面的人格特质风险评分，评估了这7个人格特质维度的综合影响。我们在最后一次随访中使用抑郁症状和BMI的单次测量以及10年以上的重复测量来测量抑郁症状和高BMI的共同发生。我们使用多项逻辑回归模型来检验暴露-结果的关联。在基线,我们纳入了1778人(平均年龄:14.4岁;女性:853人(48.0%))。在后续行动中，我们观察到抑郁症状和高BMI每增加1-SD的神经质评分（1.95-2.38比值比）或1-SD的自尊和自觉性降低（0.63-0.80比值比；所有P值<0.05）的同时发生的风险增加;我们没有观察到开放性，令人愉快，外向,或责任和同时发生抑郁症状和高BMI的风险（所有P值>0.05）。对于人格特质的7个维度的综合影响，我们发现，在人格特征风险评分中，抑郁症状和高BMI每增加1-SD的同时发生的风险升高(OR(95%CI),最后一次随访时的单次测量：2.01，1.66至2.43；使用重复测量的轨迹分类2.30，1.55至3.42；使用重复测量的平均水平：2.27，1.93至2.67）。在中国这个国家群体中，研究发现,从青春期到成年早期,人格特质与抑郁症状和高BMI的同时发生相关.这些发现强调了根据人格特质对个体进行分层并为患有抑郁症和肥胖症的人群提供有针对性的干预措施的重要性。
