Abstract：
UNASSIGNED: This study evaluated the structural and functional impact of vernal keratoconjunctivitis (VKC) on meibomian glands (MGs) using a combination of noncontact meibography and lipid layer interferometry.
UNASSIGNED: In this observational study 50 patients with moderate persistent or severe VKC and 50 age-matched controls underwent MG imaging and lipid layer thickness (LLT) measurements with Lipiview II. Image J software was used to assess MG loss (meibograde) in both lids. All patients underwent dry eye evaluation comprising tear break-up time (TBUT), ocular surface staining (OSS), Schirmer I scoring, and meiboscoring (expressibility and quality of meibum secreted).
UNASSIGNED: Meibograde, OSS score, and meiboscore was higher in cases (2.68 ± 0.96, 0.580 ± 1.07, and 0.56 ± 0.95 respectively) than controls (1.80 ± 0.67, 0.00 ± 0.00, 0.22 ± 0.47 respectively) (p < 0.001, 0.001, 0.025 respectively). LLT and TBUT was lower in cases (54.58 ± 9.43 nm and 4.92 ± 3.09 sec respectively) than controls (70.14 ± 22.50 nm and 12.02 ± 2.73 sec respectively) (both p\'s = 0.001). Both groups had comparable Schirmer I scores.
UNASSIGNED: Children with VKC have significant MG dropouts, deterioration in meibum quality and a thinner and less stable tear film. VKC patients are thus prone to a vicious cycle of inflammation attributable both to the allergic component and to deterioration in MG structure and function. Co-management of MG dysfunction warrants as much attention as the allergic component itself.
UNASSIGNED: In this observational study 50 patients with moderate persistent or severe VKC and 50 age-matched controls underwent MG imaging and lipid layer thickness (LLT) measurements with Lipiview II. Image J software was used to assess MG loss (meibograde) in both lids. All patients underwent dry eye evaluation comprising tear break-up time (TBUT), ocular surface staining (OSS), Schirmer I scoring, and meiboscoring (expressibility and quality of meibum secreted).
UNASSIGNED: Meibograde, OSS score, and meiboscore was higher in cases (2.68 ± 0.96, 0.580 ± 1.07, and 0.56 ± 0.95 respectively) than controls (1.80 ± 0.67, 0.00 ± 0.00, 0.22 ± 0.47 respectively) (p < 0.001, 0.001, 0.025 respectively). LLT and TBUT was lower in cases (54.58 ± 9.43 nm and 4.92 ± 3.09 sec respectively) than controls (70.14 ± 22.50 nm and 12.02 ± 2.73 sec respectively) (both p\'s = 0.001). Both groups had comparable Schirmer I scores.
UNASSIGNED: Children with VKC have significant MG dropouts, deterioration in meibum quality and a thinner and less stable tear film. VKC patients are thus prone to a vicious cycle of inflammation attributable both to the allergic component and to deterioration in MG structure and function. Co-management of MG dysfunction warrants as much attention as the allergic component itself.
摘要：
■本研究使用非接触膜图和脂质层干涉法的组合评估了春季角膜结膜炎（VKC）对睑板腺（MGs）的结构和功能影响。
■在这项观察性研究中，50名中度持续性或重度VKC患者和50名年龄匹配的对照者接受了LipiviewII的MG成像和脂质层厚度（LLT）测量。图像J软件用于评估两个盖子中的MG损失(miibograde)。所有患者均接受干眼评估，包括泪液破裂时间（TBUT），眼表染色（OSS），Schirmer我得分，和meiboscoring（美脂分泌的可表达性和质量）。
■Meibograde，OSS评分,病例中meiboscore（分别为2.68±0.96、0.580±1.07和0.56±0.95）高于对照组（分别为1.80±0.67、0.00±0.00、0.22±0.47）（分别为p<0.001、0.001、0.025）。病例的LLT和TBUT（分别为54.58±9.43nm和4.92±3.09sec）低于对照组（分别为70.14±22.50nm和12.02±2.73sec）（均p\s=0.001）。两组均具有可比的SchirmerI评分。
■患有VKC的儿童有明显的MG辍学，meibum质量恶化，泪膜更薄、更不稳定。因此,VKC患者易于发生由过敏成分和MG结构和功能恶化引起的炎症的恶性循环。MG功能障碍的共同管理需要与过敏成分本身一样多的关注。
■在这项观察性研究中，50名中度持续性或重度VKC患者和50名年龄匹配的对照者接受了LipiviewII的MG成像和脂质层厚度（LLT）测量。图像J软件用于评估两个盖子中的MG损失(miibograde)。所有患者均接受干眼评估，包括泪液破裂时间（TBUT），眼表染色（OSS），Schirmer我得分，和meiboscoring（美脂分泌的可表达性和质量）。
■Meibograde，OSS评分,病例中meiboscore（分别为2.68±0.96、0.580±1.07和0.56±0.95）高于对照组（分别为1.80±0.67、0.00±0.00、0.22±0.47）（分别为p<0.001、0.001、0.025）。病例的LLT和TBUT（分别为54.58±9.43nm和4.92±3.09sec）低于对照组（分别为70.14±22.50nm和12.02±2.73sec）（均p\s=0.001）。两组均具有可比的SchirmerI评分。
■患有VKC的儿童有明显的MG辍学，meibum质量恶化，泪膜更薄、更不稳定。因此,VKC患者易于发生由过敏成分和MG结构和功能恶化引起的炎症的恶性循环。MG功能障碍的共同管理需要与过敏成分本身一样多的关注。
