UNASSIGNED: In this observational study 50 patients with moderate persistent or severe VKC and 50 age-matched controls underwent MG imaging and lipid layer thickness (LLT) measurements with Lipiview II. Image J software was used to assess MG loss (meibograde) in both lids. All patients underwent dry eye evaluation comprising tear break-up time (TBUT), ocular surface staining (OSS), Schirmer I scoring, and meiboscoring (expressibility and quality of meibum secreted).
UNASSIGNED: Meibograde, OSS score, and meiboscore was higher in cases (2.68 ± 0.96, 0.580 ± 1.07, and 0.56 ± 0.95 respectively) than controls (1.80 ± 0.67, 0.00 ± 0.00, 0.22 ± 0.47 respectively) (p < 0.001, 0.001, 0.025 respectively). LLT and TBUT was lower in cases (54.58 ± 9.43 nm and 4.92 ± 3.09 sec respectively) than controls (70.14 ± 22.50 nm and 12.02 ± 2.73 sec respectively) (both p\'s = 0.001). Both groups had comparable Schirmer I scores.
UNASSIGNED: Children with VKC have significant MG dropouts, deterioration in meibum quality and a thinner and less stable tear film. VKC patients are thus prone to a vicious cycle of inflammation attributable both to the allergic component and to deterioration in MG structure and function. Co-management of MG dysfunction warrants as much attention as the allergic component itself.
■在这项观察性研究中,50名中度持续性或重度VKC患者和50名年龄匹配的对照者接受了LipiviewII的MG成像和脂质层厚度(LLT)测量。图像J软件用于评估两个盖子中的MG损失(miibograde)。所有患者均接受干眼评估,包括泪液破裂时间(TBUT),眼表染色(OSS),Schirmer我得分,和meiboscoring(美脂分泌的可表达性和质量)。
■Meibograde,OSS评分,病例中meiboscore(分别为2.68±0.96、0.580±1.07和0.56±0.95)高于对照组(分别为1.80±0.67、0.00±0.00、0.22±0.47)(分别为p<0.001、0.001、0.025)。病例的LLT和TBUT(分别为54.58±9.43nm和4.92±3.09sec)低于对照组(分别为70.14±22.50nm和12.02±2.73sec)(均p\s=0.001)。两组均具有可比的SchirmerI评分。
■患有VKC的儿童有明显的MG辍学,meibum质量恶化,泪膜更薄、更不稳定。因此,VKC患者易于发生由过敏成分和MG结构和功能恶化引起的炎症的恶性循环。MG功能障碍的共同管理需要与过敏成分本身一样多的关注。