UNASSIGNED: A first-in-class anti-Notch4 agent, E7011, demonstrates strong antitumor effects in murine tumor models including breast carcinoma. Endothelial Notch4 blockade reduces perfusion and vessel area.
使用新型中和抗体抑制 Notch4 通过靶向肿瘤内皮降低小鼠癌症模型中的肿瘤生长。
Mesh : Animals Receptor, Notch4 / metabolism Mice Humans Neovascularization, Pathologic / drug therapy pathology metabolism Female Antibodies, Neutralizing / pharmacology therapeutic use Cell Line, Tumor Signal Transduction / drug effects Xenograft Model Antitumor Assays Disease Models, Animal Endothelial Cells / drug effects metabolism Cell Proliferation / drug effects Breast Neoplasms / drug therapy pathology metabolism
来 源:
DOI:10.1158/2767-9764.CRC-24-0081
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