Abstract：
Topical ophthalmic solutions (eye drops) are becoming increasingly popular in treating and preventing ocular diseases for their safety, noninvasiveness, and ease of handling. However, the static and dynamic barriers of eyes cause the extremely low bioavailability (<5%) of eye drops, making ocular therapy challenging. Thus, drug-eluting corneal contact lenses (DECLs) have been intensively investigated as a drug delivery device for their attractive properties, such as sustained drug release and improved bioavailability. In order to promote the clinical application of DECLs, multiple aspects, i.e., drug release and penetration, safety, and biocompatibility, of these drug delivery systems were thoroughly examined. In this review, we systematically discussed advances in DECLs, including types of preparation materials, drug-loading strategies, drug release mechanisms, strategies for penetrating ocular barriers, in vitro and in vivo drug delivery and penetration detection, safety, and biocompatibility validation methods, as well as challenges and future perspectives.
摘要：
局部眼用溶液（滴眼剂）由于其安全性而在治疗和预防眼病方面越来越受欢迎。非侵入性，和易于处理。然而,眼睛的静态和动态屏障导致滴眼剂的生物利用度非常低（<5％），使眼部治疗具有挑战性。因此，药物洗脱角膜接触镜（DECLs）作为一种药物输送装置，因其吸引人的特性而被深入研究。如持续的药物释放和改善的生物利用度。为了促进DECLs的临床应用,多个方面,即，药物释放和渗透，安全,和生物相容性，对这些药物递送系统进行了彻底检查。在这次审查中,我们系统地讨论了DECL的进展，包括准备材料的类型，药物装载策略，药物释放机制，穿透眼屏障的策略，体外和体内药物递送和渗透检测，安全,和生物相容性验证方法，以及挑战和未来前景。
