Abstract：
UNASSIGNED: Iron deficiency affects more than 60% of colorectal cancer patients at the time of diagnosis. Iron deficiency ultimately leads to anemia, but additionally, iron deficiency might impact other domains of colorectal cancer patients\' health and well-being. The aim of this study was to evaluate the impact of iron deficiency on fatigue, quality of life, cognition, and physical ability in patients undergoing evaluation for colorectal cancer.
UNASSIGNED: Multicenter, prospective, observational cross-sectional study (2021-2023). Fatigue was the primary outcome, measured using the Focused Assessment of Cancer Treatment-Anemia questionnaire (FACT-An). Quality of Life, Cognition, Aerobe capacity, mobility, and peripheral muscle strength were tested as secondary outcomes. Multivariate analysis was performed to estimate the impact of iron deficiency on all outcomes.
UNASSIGNED: Two hundred and one patients were analyzed, 57% being iron deficient. In multivariate regression analysis, iron deficiency was not associated with fatigue: FACT-An (r = -1.17, p = 0.57, 25% CI: -5.27 to 2.92). Results on quality of life, cognition, and mobility were non-significant and with small regression coefficients. Iron deficiency showed a nearly significant association with reduced hand-grip-strength (r = -3.47 kg, p = 0.06, 25%CI -7.03 to 0.08) and reduced 6 min walking distance (r = -40.36 m, p = 0.07, 25%CI: -84.73 to 4.00).
UNASSIGNED: Iron deficiency in patients undergoing evaluation for colorectal cancer was not associated with fatigue, quality of life, or cognition, but might affect aerobic endurance and peripheral muscle strength to a degree that is clinically relevant.
UNASSIGNED: Multicenter, prospective, observational cross-sectional study (2021-2023). Fatigue was the primary outcome, measured using the Focused Assessment of Cancer Treatment-Anemia questionnaire (FACT-An). Quality of Life, Cognition, Aerobe capacity, mobility, and peripheral muscle strength were tested as secondary outcomes. Multivariate analysis was performed to estimate the impact of iron deficiency on all outcomes.
UNASSIGNED: Two hundred and one patients were analyzed, 57% being iron deficient. In multivariate regression analysis, iron deficiency was not associated with fatigue: FACT-An (r = -1.17, p = 0.57, 25% CI: -5.27 to 2.92). Results on quality of life, cognition, and mobility were non-significant and with small regression coefficients. Iron deficiency showed a nearly significant association with reduced hand-grip-strength (r = -3.47 kg, p = 0.06, 25%CI -7.03 to 0.08) and reduced 6 min walking distance (r = -40.36 m, p = 0.07, 25%CI: -84.73 to 4.00).
UNASSIGNED: Iron deficiency in patients undergoing evaluation for colorectal cancer was not associated with fatigue, quality of life, or cognition, but might affect aerobic endurance and peripheral muscle strength to a degree that is clinically relevant.
摘要：
■缺铁会在诊断时影响60％以上的结直肠癌患者。缺铁最终导致贫血,但另外，缺铁可能会影响结直肠癌患者的其他领域的健康和福祉。这项研究的目的是评估缺铁对疲劳的影响，生活质量,认知，接受结直肠癌评估的患者的身体能力。
■多中心，prospective,观察性横断面研究（2021-2023年）。疲劳是主要结果，使用重点评估癌症治疗-贫血问卷（FACT-An）进行测量。生活质量,认知,Aerebecapacity,移动性,和外周肌力作为次要结局进行测试.进行多因素分析以估计缺铁对所有结局的影响。
■分析了200名患者，57%缺铁。在多元回归分析中，铁缺乏与疲劳无关：FACT-An（r=-1.17，p=0.57，25％CI：-5.27至2.92）。关于生活质量的结果，认知，和流动性不显著，回归系数小。缺铁与手握力降低几乎显着相关（r=-3.47kg，p=0.06，25CI-7.03至0.08）并减少6分钟步行距离（r=-40.36m，p=0.07，25CI：-84.73至4.00）。
■接受结直肠癌评估的患者缺铁与疲劳无关，生活质量,或认知，但可能会影响有氧耐力和外周肌肉力量，达到临床相关的程度。
■多中心，prospective,观察性横断面研究（2021-2023年）。疲劳是主要结果，使用重点评估癌症治疗-贫血问卷（FACT-An）进行测量。生活质量,认知,Aerebecapacity,移动性,和外周肌力作为次要结局进行测试.进行多因素分析以估计缺铁对所有结局的影响。
■分析了200名患者，57%缺铁。在多元回归分析中，铁缺乏与疲劳无关：FACT-An（r=-1.17，p=0.57，25％CI：-5.27至2.92）。关于生活质量的结果，认知，和流动性不显著，回归系数小。缺铁与手握力降低几乎显着相关（r=-3.47kg，p=0.06，25CI-7.03至0.08）并减少6分钟步行距离（r=-40.36m，p=0.07，25CI：-84.73至4.00）。
■接受结直肠癌评估的患者缺铁与疲劳无关，生活质量,或认知，但可能会影响有氧耐力和外周肌肉力量，达到临床相关的程度。
